Abstract:Diabetes mellitus, as a common metabolic and endocrine disorder, can lead to various severe complications,impacting patients' quality of life. Although there are multiple hypoglycemic drugs available for clinical use, these medications all have varying degrees of adverse reactions. In recent years, with the deepening research on edible fungal proteins, their potential in lowering blood sugar has gradually attracted the attention of the scientific community. This article reviews the mechanisms of edible fungal proteins in regulating glucose metabolism through pathways such as modulating immunity, regulating the body's utilization of glucose, modulating insulin signaling pathways, and alleviating oxidative inflammatory responses, aiming to provide safer and more effective treatment options for patients with diabetes.