近年来，高尿酸血症发生率逐年攀升，严重影响人类健康。前期研究报道的结果表明：粗毛纤孔菌游离酚提取物具有较强体外降尿酸活性，但仍缺少体内实验验证。为此，该研究通过选用高尿酸小鼠模型饲料饲养结合灌胃氧嗪酸钾干预4周，建立高尿酸血症小鼠模型，探究粗毛纤孔菌游离酚提取物体内的降尿酸作用。研究结果表明：经栽培粗毛纤孔菌游离酚提取物灌胃干预4周，粗毛纤孔菌游离酚提取物高剂量组［200 mg/(kg•bw)］小鼠血清的尿酸含量、尿素氮含量、腺苷脱氨酶及肝脏黄嘌呤氧化酶较模型组小鼠相比分别降低了65.99%、43.68%、67.31%、89.73%（P<0.05），其调节作用与药物对照-别嘌醇相当；此外，粗毛纤孔菌游离酚提取物还对由高尿酸血症引起的肾脏组织细胞损伤产生一定的修复作用。因此，粗毛纤孔菌游离酚提取物可能具有较好的降尿酸作用。该研究结果可为桑黄孔菌属真菌作为新型降尿酸功能食品资源的开发提供理论参考。

In recent years, there has been an increasing incidence of hyperuricemia, which affects seriously human health. The results of previous studies have shown that the free phenol extract of Inonotus hispidus has a strong in vitro uric acid-lowering activity, but there is still a lack of in vivo experimental verification. Accordingly, a hyperuricemia mouse model was established in this study by feeding the mice a high uric acid mouse feed combined with the gavage of oteracil potassium for 4 weeks, in order to determine the in vivo uric acid-lowering effect of the free phenolic extract of Inonotus hispidus. The results showed that after 4 weeks of intervention with the extract, the levels of serum uric acid, serum urea nitrogen and serum adenosine deaminase, and the activity of hepatic xanthine oxidoreductase of the mice in the high-dose group of Inonotus hispidus free phenolic extract [200 mg/(kg•bw)] were significantly reduced (by 65.99%, 43.68%, 67.31%, and 89.73% respectively, P<0.05) compared to the model group, with its regulatory effectbeing comparable to that of allopurinol (positive drug control). In addition, the free phenol extract also demonstrated a certain restorative effect on the cell damage of the kidney tissue caused by hyperuricemia. Therefore, the Inonotus hispidus free phenolic extract may have a good uric acidlowering effect. The results of this study can provide a theoretical reference for the development of novel uric acid-lowering functional food resources using Sanghuangporus spp.

广东省重点领域研发计划项目（2020B020225005）；广东省农业科学院新兴学科团队建设项目（202119TD）；广东省科技计划项目（2023B0202010004）；广东省农业科学院优秀博士项目（R2021YJ-YB1002）；佛山市财政专项资金-2022年高水平广东省农业科技示范市建设资金市院合作项目