Abstract:In recent years, there has been an increasing incidence of hyperuricemia, which affects seriously human health. The results of previous studies have shown that the free phenol extract of Inonotus hispidus has a strong in vitro uric acid-lowering activity, but there is still a lack of in vivo experimental verification. Accordingly, a hyperuricemia mouse model was established in this study by feeding the mice a high uric acid mouse feed combined with the gavage of oteracil potassium for 4 weeks, in order to determine the in vivo uric acid-lowering effect of the free phenolic extract of Inonotus hispidus. The results showed that after 4 weeks of intervention with the extract, the levels of serum uric acid, serum urea nitrogen and serum adenosine deaminase, and the activity of hepatic xanthine oxidoreductase of the mice in the high-dose group of Inonotus hispidus free phenolic extract [200 mg/(kg•bw)] were significantly reduced (by 65.99%, 43.68%, 67.31%, and 89.73% respectively, P<0.05) compared to the model group, with its regulatory effectbeing comparable to that of allopurinol (positive drug control). In addition, the free phenol extract also demonstrated a certain restorative effect on the cell damage of the kidney tissue caused by hyperuricemia. Therefore, the Inonotus hispidus free phenolic extract may have a good uric acidlowering effect. The results of this study can provide a theoretical reference for the development of novel uric acid-lowering functional food resources using Sanghuangporus spp.
