为提高蜂蜜等药食同源资源的开发利用，以蜂蜜、桑叶、玉竹、陈皮、桑椹、百合等为原料，研制一款具有止咳、化痰功效的蜂蜜复合浓缩原浆。以感官评价为指标，采用正交试验和响应面试验对产品配方及工艺进行优化。通过小鼠氨水引咳实验、酚红排泌实验对产品止咳、化痰功能进行评价。结果表明，蜂蜜复合浓缩原浆最佳配方为：蜂蜜添加量7.0 g、浓缩原浆添加量7.0 g、浓缩调味果汁添加量3.5 g。最佳加工工艺为：抽滤次数3次，浓缩时间60 min，浓缩温度60 ℃。产品能显著延长小鼠咳嗽潜伏期，减少2 min内小鼠咳嗽次数，提高小鼠酚红排泌能力，高、中、低剂量组咳嗽抑制率分别为36.18%、26.63%、26.38%。本研究制得的蜂蜜复合浓缩原浆风味独特，清甜宜口，具有良好的止咳化痰活性。

In order to improve the development and utilization of honey and other medicine and food homologous resources, honey, mulberry leaves, Polygonatum odoratum, dried tangerine peel, mulberry and lily were used as raw materials to develop a honey composite concentrated pulp with the efficacy of relieving cough and resolving phlegm. Sensory evaluation taken as the dependent variable, the formula and process were optimized by orthogonal test and response surface test. The antitussive and expectorant activity of the product were evaluated by ammonia-induced cough test and phenol red excretion test in mice. The results showed that the optimal formulation of the honey composite concentrated pulp was 7.0 g of honey, 7.0 g of concentrated pulp, and 3.5 g of concentrated flavored juice, and the optimal process was 3 times of pumping filtration, 60 min of concentration time, and 60 ℃ of concentration temperature. The product can significantly prolong the cough latency of mice, reduce the number of coughs in mice within 2 min, and improve the phenol red excretion ability of mice. The cough inhibition rates of high, medium and low dose groups were respectively 36.18%, 26.63% and 26.38%. The honey composite concentrated pulp has unique flavor, sweet taste, good antitussive and expectorant activity.

中央引导地方科技发展专项资金项目（2020ZYD058）；四川省科技厅应用基础研究项目(2018JY0255)；成都中医药大学“杏林学者"学科人才科研提升计划项目(XCZX2022013)。