Abstract:The regulatory effects of plant extract A on menopausal syndrome, particularly osteoporosis, was investigated. A menopausal rat model was established through ovariectomy, followed by continuous gavage for 14 weeks. Five groups, comprising blank group, control group, and low-, medium-, and high-dose groups, were designated. The results revealed that plant extract A improved the uterine condition of menopausal rats by regulating the secretion of sex hormones, leading to increased serum estradiol (33.33%) and serum anti-Müllerian hormone (134.78%) levels, and decreased serum follicle stimulating hormone (8.42%) levels. Additionally, plant extract A enhanced the structures and functions of bone tissues in menopausal rats. It also increased total bone mineral density (8.00%), distal bone mineral density (7.69%), and midshaft bone mineral density (8.33%), as well as the levels of blood phosphorus (14.04%), calcium (12.58%), bone calcium (34.87%) and serum 25-hydroxy vitamin D (78.40%) levels, fibroblast growth factor (60.21%), procollagen I N-terminal pro-peptide (128.57%), alkaline phosphatase (40.00%), and osteocalcin (51.61%) in menopausal rats. However, it reduced the level of C-terminal telopeptide of type I procollagen (34.22%). In conclusion, plant extract A can effectively regulate the secretion of sex hormones in menopausal rats and alleviate osteoporosis symptoms. This study offers valuable insights into the potential promotion and application of plant extract A as a functional food to mitigate menopausal syndrome symptoms.
