该文通过直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验以及巴比妥钠睡眠潜伏期实验比较了酸枣仁提取物、龙眼肉提取物和γ-氨基丁酸的改善睡眠效果。结果显示，3种功能因子所有剂量组均对直接睡眠无明显作用，对小鼠体质量也均无显著性影响，但是3种功能因子中γ-氨基丁酸高中低剂量33.3 mg/(kg•d)、16.7 mg/(kg•d)和8.3 mg/(kg•d）、酸枣仁提取物高中剂量110 mg/(kg•d)和55 mg/(kg•d)和龙眼肉低剂量组66.5 mg/(kg•d)均可显著延长戊巴比妥钠诱导的小鼠睡眠时间，γ-氨基丁酸对小鼠戊巴比妥钠阈下剂量催眠作用最大，12只小鼠中高中低剂量均有2只入睡，睡眠发生率达到16.67%，酸枣仁提取物高中低剂量组均可缩短巴比妥钠催眠的小鼠的入睡潜伏期，但仅高剂量组和中剂量与对照组比较差异有统计学意义（P<0.05）。

Sleep improvement effect of Semen Ziziphi Spinosae extract, longan aril extract, and γ-aminobutyric acid. were compared through direct sleep, sodium pentobarbital-induced sleep extension, subthreshold dose sodium pentobarbital-induced hypnosis, and sodium barbital-induced sleep latency experiments were carried out. The results showed that all three functional formulations had no significant effect on the direct sleep and body weight of mice. However, the high (33.3 mg/kg•d), medium (16.7 mg/kg•d), and low dose (8.3 mg/kg•d) of γ-aminobutyric acid, the high (110 mg/kg•d) and medium (55 mg/kg•d dose of Semen Ziziphi Spinosae extract, as well as the low dose (66.5 mg/kg•d) of longan aril extract could significantly prolong the sodium pentobarbital-induced sleep time of mice. Further, γ-aminobutyric acid had the greatest hypnotic effect on mice treated with the subthreshold dose of sodium pentobarbital. Among the 12 mice tested, 2 fell asleep at high, medium, and low doses of γ-aminobutyric acid. Thus, the incidence of sleep reached 16.67%. The high, medium, and low dose of Semen Ziziphi Spinosae extract could shorten the sleep latency of mice hypnotized by sodium barbital, whereas only the high- and medium-dose groups were significantly different from the control group (P<0.05).

国家自然科学基金项目（31201416；31972065）