以高脂血症大鼠为模型，研究磷虾油和红曲提取物降血脂的功效。将雄性大鼠分为12组（n=10），阴性对照组与模型组给予w=0.9%生理盐水，药物组灌胃w=0.01%的辛伐他丁，磷虾油干预组每日分别灌胃83.33、166.67、500.00 mg/kg磷虾油，红曲提取物组每日灌胃33.33、66.67、200.00 mg/kg红曲提取物，混合物组每日分别灌胃166.67+33.33、166.67+66.67、166.67+200.00 mg/kg磷虾油+红曲提取物。阴性对照组给予正常饲料，其余各组给予高脂饲料。干预四周后进行测定。结果显示经磷虾油提取物、红曲提取物和混合提取物干预后，血液TC、TG和LDL-C显著降低，且呈现剂量依赖，说明磷虾油、红曲提取物以及混合提取物有辅助降血脂功能。磷虾油低剂量组、红曲高剂量组、混合物高剂量组和辛伐他丁药物组大鼠血清ALT和AST含量较模型组显著降低，其中混合物高剂量组（166.67+200.00 mg/kg）效果最佳，TC由4.14 mmol/L下降到3.37 mmol/L，TG由2.77 mmol/L下降到1.51 mmol/L、LDL-C由0.37 mmol/L下降到0.25 mmol/L。因此磷虾油和红曲提取物混合物降血脂效果优于单一组分，可用于辅助降血脂产品的应用。

The hypolipidemic effects of krill oil and extract from Monascus spp. on rats with hyperlipidemia were examined. Male rats were divided into 12 groups (n=10). The negative control and model groups were given 0.9% saline solutions, whereas the drug-treated group was given 0.01% simvastatin. The krill oil-treated groups were treated with 83.33, 166.67, and 500.00 mg/kg of krill oil daily by intragastric administration, and the Monascus extract-treated groups were similarly given 33.33, 66.67, and 200.00 mg/kg of Monascus extract daily. Similarly, the mixed treatment groups received 166.67+33.33, 166.67+66.67, and 166.67+200.00 mg/kg of krill oil+Monascus extract daily by intragastric administration. The negative control group was given a normal diet, whereas the other groups were given a high-fat diet. Measurements were performed after four weeks of treatment. The results showed that, after treatment with krill oil, Monascus extract, and their mixtures, the levels of blood TC, TG, and LDL-C decreased significantly; this decrease was dose-dependent. Therefore, krill oil, Monascus extract, and their mixtures can assist in reducing lipids in the blood. The serum contents of ALT and AST in the low-dosage krill oil, high-dosage Monascus extract, high-dosage mixture, and simvastatin groups were significantly lower than those in the model group. The group treated with high-dosage krill oil+Monascus extract mixture (166.67+200.00 mg/kg krill oil+Monascus extract) demonstrated the most significant reductions in the levels of TC (from 4.14 mmol/L to 3.37 mmol/L), TG (from 2.77 mmol/L to 1.51 mmol/L), and LDL-C (from 0.37 mmol/L to 0.25 mmol/L). Therefore, the hypolipidemic effect of the mixture of krill oil and Monascus extract is higher than that of the individual components. This finding enables the mixture to be utilized as an auxiliary hypolipidemic agent.

广东省重点领域研发计划项目（2020B020226008）；广东省自然科学基金面上项目（2020A1515011268）