为探究粉剂型全营养特医食品喷雾干燥，获得粉剂型全营养特医食品喷雾干燥制粉最佳工艺，以Vc包埋率、油脂包埋率作为评价指标，利用Box-Behnken中心组合方法对喷雾干燥工艺条件进行优化，考察进风温度、进样速度、进样浓度以及风速对粉剂型全营养特医食品的影响，确定最佳喷雾干燥工艺条件，并以普通干法混合作为对照，探究不同加速试验（高温、高湿、开袋）条件下喷雾干燥法制备的全营养特医食品的储藏稳定性。研究结果表明，全营养特医食品湿法喷雾干燥加工最佳工艺条件为：进样浓度24%、进风温度132 ℃、进样速度13.5 mL/min、风速30 Hz。该工艺制备的全营养特医食品Vc包埋率和油脂包埋率为79.72%和92.25%，混合均匀度可高达99.68%。加速试验结果显示，该加工工艺较普通干法混合能够有效减缓脂肪氧化和Vc含量的损失，提高粉体的储藏稳定性。该研究结果可为提升粉剂型全营养特医食品品质提供技术支撑。

The effects of different processing parameters on the quality of powdered total-nutrition food for special medical purposes (FSMP) during the spray drying process were investigated to obtain the optimal preparation process for the spray-dried powder of total-nutrition FSMP. Using vitamin C (Vc) and oil encapsulation rates as evaluation indexes for powder quality, the spray drying processing parameters were optimized based on the Box-Behnken central composite method. The effects of spray drying parameters, such as inlet air temperature, injection speed, injection concentration, and air velocity, on the quality of powdered total-nutrition FSMP were investigated to determine the optimal spray drying process conditions. The storage stability of total-nutrition FSMP prepared by spray drying under different accelerated test conditions (high temperature, high humidity, and bag opening) were studied using the conventional dry mixing method as the control. The results showed that the optimal process conditions for wet spray drying of total-nutrition FSMP were injection concentration at 24%, inlet temperature of 132 ℃, injection speed of 13.5 mL/min, and air velocity of 30 Hz. The Vc and oil encapsulation rates of total-nutrition FSMP prepared using this process were 79.72% and 92.25%, respectively, and the blend uniformity was up to 99.68%. The results of accelerated testing demonstrated that compared to conventional dry mixing, this technique could effectively slow down lipid oxidation and the loss of Vc content, while also improving the storage stability of the powder. Therefore, our findings can provide technical support for improving the quality of powdered total-nutrition FSMP.

广东特支计划本土创新创业团队项目（2019BT02N112）；广东省重点研发计划项目（2019B020213002）；茂名市科技计划项目（mmkj2020001）