人体铁吸收及植物铁蛋白补铁特性研究进展

Research Progress on Iron Absorption in Human Body and Unique Properties of Plant Ferritin for Iron Supplementation

摘要:

缺铁性贫血依然为全球目前所面临的公共健康营养问题之一，而铁营养作用的发挥与其吸收利用度密切相关。植物铁蛋白以其独特的笼形结构，在补铁方面拥有广阔的应用前景。该研究主要综述人体对各种来源的铁的吸收途径，以及植物铁蛋白的结构及其补铁特性。关于机体铁吸收的途径着重从血红素铁及Fe2+、Fe3+、铁蛋白等非血红素铁的角度介绍人体对不同来源铁的吸收方式，并进一步介绍影响铁吸收的因素；之后对植物铁蛋白的基本结构及其与动物铁蛋白相比之下的特殊结构进行阐述；最后针对植物铁蛋白在细胞实验、动物实验及临床研究等各方面的补铁特性以及其在纳米包埋领域的应用进行总结。该综述旨在为机体铁代谢及植物铁蛋白营养特性的深入研究奠定一定的基础。

Abstract:

Iron-deficiency anemia is still one of the public problems related to health nutrition currently facing the world, and the nutritional function of iron is closely related to its absorption and utilization in the body. Plant ferritin, with its unique cage structure, has broad application prospects in iron supplementation. This article reviews mainly the absorption pathways of iron from various sources by the human body, the structure of plant ferritin and its characteristics as an iron supplement. Regarding the ways of iron absorption in the body, a focus is placed on the absorption approach in the human body for iron from various sources, such as heme iron and non-heme irons like Fe2+, Fe3+ and ferritin. Moreover, the factors affecting the iron absorption were also reviewed. Then, the basic structure of plant ferritin and its special structure compared with animal ferritin are described. Finally, t he iron supplementation characteristics of plant ferritin exhibited in cell experiments, animal experiments and clinical research, and its application in the field of ano-encapsulation are summarized. The purpose of this review is to lay a foundation for in-depth study on the body’s iron metabolism and nutritional characteristics of plant ferritin.