马铃薯抗性淀粉对高脂血症大鼠的降血糖血脂作用

Hypoglycemic and Lipid Lowering Effects of Potato Resistant Starch on Hyperlipidemia Rats

摘要:

探究马铃薯抗性淀粉对高脂血症大鼠的降血糖血脂作用，48只大鼠，按体重随机分成空白对照组和模型对照组，高脂饲料饲喂2周后按总胆固醇(TC)水平随机分为5组：高脂模型组，阳性对照组，马铃薯抗性淀粉高、中、低剂量组。干预6周，测定各组大鼠的体质量、肝脏系数、血脂水平等指标，并观察大鼠肝脏组织病理切片。结果发现，与空白组比较，高脂组体重增加2.21%；心脏、肝脏、肝脏系数、附睾周脂重均有所增加，分别为23.70%、85.84%、63.88%、23.74%；TC、TG、LDL-C及血糖水平升高；高脂模型建立成功。与高脂组比较，实验组体重、肝脏重量、肝脏系数、附睾周脂重降低，降低最大幅度分别为2.50%、14.18%、9.18%、19.46%；TC、TG、LDL-C、AI及血糖水平显著降低，最大幅度分别为29.84%、49.33%、59.21%、43.89%、11.33%，HDL-C无显著差异。HE 染色结果显示，与高脂组比较，高、中剂量组大鼠肝脏脂肪变性程度明显改善。表明马铃薯抗性淀粉能降低血糖血脂水平，对高脂血症的预防及治疗具有积极作用。

Abstract:

To explore the hypoglycemic and blood lipid-lowering effects of potato resistant starch on hyperlipidemia rats, 48 rats were randomly divided into a blank control group and a model control group according to their body weights. After 2 weeks of high-fat feeding, they were randomly divided into 5 groups according to the total cholesterol (TC) level: high-fat model group, positive control group, and potato resistant starch high-, medium-, and low-dose groups. After 6 weeks of intervention, the body weights, liver coefficients, blood lipid levels and other indicators of the rats in each group were measured, and the pathological tissue sections of their livers were examined. Results: Compared with the blank group, the body weight of the high-fat group increased by 2.21%, the heart weight, liver weight, liver coefficient, and periepididymal fat weight all increased by 23.70%, 85.84%, 63.88% and 23.74%, respectively; TC, TG, LDL-C and blood sugar levels increased; The high-fat model was successfully established. Compared with the high-fat group, the experimental group's body weight, liver weight, liver coefficient, and periepididymal fat weight decreased, with the largest reductions being 2.50%, 14.18%, 9.18%, and 19.46%, respectively; The levels of TC, TG, LDL-C, AI and blood sugar were significantly reduced, and the largest reductions were 29.84%, 49.33%, 59.21%, 43.89% and 11.33%, respectively, with no significant difference found in HDL-C. The results of HE staining experiments showed that compared with the high-fat group, the degrees of liver steatosis in the rats of the high- and medium-dose groups were significantly improved. The results showed that potato resistant starch can lower the blood sugar and blood lipid levels, and makes a positive contribution to the prevention and treatment of hyperlipidemia.