刺梨口服液对消化不良小鼠胃肠动力的促进作用

Effect of Rose roxburghii Tratt Oral Liquid on Gastrointestinal Motility in Dyspepsia Mice

摘要:

研究刺梨口服液对消化不良小鼠胃肠动力的促进作用。通过复方地芬诺酯诱导消化不良模型小鼠，将造模成功的小鼠分成模型组（MC）、阳性组（PC）、刺梨口服液（DF）、刺梨口服液（HF）、正常组（NC）；正常组及模型组灌胃配制生理盐水，阳性组灌胃多藩立酮悬浮液；刺梨口服液DF、HF灌胃口服液；造模前后测量小鼠的饮食量及体质量；给药结束后，测量小鼠胃残留率及小肠运动率、血清胃动素MTL、胃泌素GAS含量评价其促消化功效。研究发现：与MC相比，DF、HF的小鼠饮食量增加了4.42%、10.38%、体质量5.87%、7.08%（p<0.05）；胃残留率降低了45.15%、36.90%，小肠推进率提升39.28%、45.11%（p<0.05）；血清含量MTL、GAS增量了35.94%、39.05%、32.14%、38.45%（p<0.05）；研究证明刺梨口服液具备较好的促消化作用，可有效促进胃肠动力运动效果。

Abstract:

To study the effect of R.roxburghii Tratt on gastrointestinal motility in indigestion mice. The successful mice were divided into model group (MC), positive group (PC), R.roxburghii Tratt oral solution (DF), R.roxburghii Tratt oral solution (HF) and normal group (NC). Normal group and model group were given normal saline, and positive group was given dofarione suspension. R.roxburghii Tratt oral liquid DF, HF groups were gavaged with oral liquid; the diet and body mass of mice were measured before and after the modeling. After the end of administration, the gastric residual rate, small intestinal motility rate, serum motilin MTL and gastrin GAS were measured to evaluate the effect of promoting digestion. It was found that compared with MC, the diet of DF and HF mice increased by 4.42%, 10.38%, 5.87% and 7.08% respectively (p<0.05). The gastric residue reduced by 45.15% and 36.90%, and the small intestinal advance rate increased by 39.28% and 45.11% (p<0.05), respectively. Serum MTL and GAS levels increased by 35.94%, 39.05%, 32.14% and 38.45%, respectively (p<0.05). Studies have shown that R. roxburghii Tratt oral liquid has a good effect of promoting digestion and effectively promoting gastrointestinal motility.