本文研究了富含α-亚麻酸（ALA）的亚麻籽油（FO）对多囊卵巢综合征（PCOS）大鼠胰岛素抵抗和氧化应激水平的影响。采用来曲唑造模法建立PCOS大鼠模型，建模成功后，FO对照组和FO干预模型组灌胃FO 8 W；阴性对照组和模型组灌胃等量生理盐水。干预结束后，检测各组大鼠血液中性激素、血脂、胰岛素抵抗与氧化应激指标含量。结果显示，膳食FO干预后雄激素（T）、胆固醇（TC）、甘油三酯（TG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）和丙二醛（MDA）水平较模型组显著降低至3.26 nmoL/mL、1.78 mmoL/mL、1.45 mmoL/mL、5.37 mIU/L、1.22和5.33 nmoL/mL（p<0.05）；雌二醇（E2）和抗氧化指标总抗氧化能力（T-AOC）、谷胱甘肽过氧化物酶（GSH-Px）和总超氧化物歧化酶（T-SOD）升高至26.54 pmoL/mL、5.11 U/mL、372.10酶活力单位和80.29 U/mL（p<0.05）。本研究表明膳食FO能够改善PCOS大鼠的胰岛素抵抗和氧化应激状态。

In this study, the effects of flaxseed oil (FO) rich in α-linolenic acid (ALA) on insulin resistance and oxidative stress level in polycystic ovary syndrome (PCOS) rats were investigated. The PCOS rat model was established by the letrozole modeling method. After successful modeling, the FO control group and the FO intervention model group were administered with FO by gavage for 8 W, while the negative control group and the model group were fed the same amount of normal saline. After the intervention, the contents of sex hormones, blood lipids, as well as the contents of insulin resistance and oxidative stress indicators of the different groups of rats were detected. The results showed that after the dietary FO intervention, the levels of androgen (T), cholesterol (TC), triglyceride (TG), fasting insulin (FINS), insulin resistance index (HOMA-IR) and malondialdehyde (MDA) decreased to 3.26 nmoL/mL, 1.78 mmoL/mL, 1.45 mmoL/mL, 5.37 mIU/L, 1.22 and 5.33 nmoL/mL, respectively, compared with model group, whilst the levels of estradiol (E2), and antioxidant indices total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD), increased to 26.54 pmoL/mL, 5.11 U/mL, 372.10 enzyme activity unit and 80.29 U/mL, respectively, compared with the model group (p<0.05). This study showed that dietary FO ameliorates insulin resistance and oxidative stress in PCOS rats.

国家自然科学基金项目（81602713）；国家重点研发计划项目（2016YFD0400605）；宁夏“十三五”重大科技项目（2016BZ02）；宁夏高等学校一流学科建设（宁夏医科大学西部一流建设学科基础医学）资助项目（NXYLXK2017B07）