不同淀粉的壳聚糖/淀粉复合薄膜结构性能比较

Structure and Property of Chitosan/Starch Composite Film with Different Kinds of Starch

摘要:

为改善功能因子的生物利用率，本文采用流延法，分别将壳聚糖（分子量150000 g/mol）与玉米淀粉、马铃薯淀粉和木薯淀粉制备复合薄膜及其包衣片剂，并通过红外光谱、扫描电镜、拉伸仪、模拟消化实验等手段对壳聚糖/淀粉复合薄膜结构性能进行分析。借助壳聚糖上的-NH3+与淀粉的-OH间的氢键作用，可形成壳聚糖/淀粉复合结构，受淀粉结构差异的影响，复合薄膜中壳聚糖/淀粉复合结构的有序性存在差异，进而影响复合薄膜的机械力学性能、耐酸性及其薄膜包衣片剂的控释性能。其中，复合薄膜CTS/Potato、CTS/Tapioca中壳聚糖/淀粉复合结构的有序性优于复合薄膜CTS/Corn，其耐酸性能良好，在模拟胃液中运转2 h，薄膜的损失率分别在18.71%~26.15%、16.14%~19.64%之间。同时，这两种复合薄膜包衣片剂的控释性能亦表现良好，约有60%的模型功能因子可顺利递送至小肠、结肠部位，具有作为药物、活性功能因子小肠、结肠定向释放载体材料的可能。

Abstract:

To improve the bioavailability of drug or bioactive component, in this work, composite films with 150,000 g/mol chitosan and three different kinds of starch were prepared by casting method. The characteristics were analyzed by FTIR, SEM, tensile test and in vitro releasing test. By the hydrogen bond between -NH3+ of chitosan and -OH of starch, there was formed chitosan/starch composite structure in the film. Due to difference in starch structure, the order of chitosan/starch composite structure was changed, which further affected the mechanical properties, acid resistance and controlled-releasing properties of the film. Results showed that the order of CTS/Potato and CTS/Tapioca composite film structure was better than that of CTS/Corn. The CTS/Potato and CTS/Tapioca composite film also showed a good acid resistance in simulated stomach fluid (film loss at the range of 18.71%~26.15% and 16.14%~19.64%, respectively) and a well-controlled-releasing property of theirs film-coated tablet (about 60% of the model bioactive component releasing in small intestine or colon), which could be potential to bioactive component for small intestine or colon site delivery.