黄须菜对高血脂症大鼠的降脂作用

Lipid-lowering Effects of Suaeda sulsa on Hyperlipidemia Rats

摘要:

本研究探讨了黄须菜对高脂血症大鼠血脂的影响，为黄须菜在预防及治疗高血脂方面提供参考依据。56只雄性SD大鼠随机平分为7组：正常组、黄须菜预防组、高脂模型组，阳性对照组，黄须菜高、中、低3个干预组。除正常组和预防组外，其余各组饲喂高脂饲料建模，实验期间采用经口灌胃给药方式，正常组和模型组灌胃等量蒸馏水。干预6周后，分别测定各组大鼠的体重、摄食量、肝重、附睾周脂重及血清血脂水平。结果：与高脂模型组相比，黄须菜干预组及预防组的体重、摄食量、肝重、附睾周脂重均有下降，其最大降幅分别为：22.20%、34.72%、37.17%、60.06%。血脂方面，较高脂模型组，黄须菜干预组与预防组均能使TC、TG、LDL-C值降低，其最大降幅分别为：33.58%、54.27%、65.26%，使HDL-C升高，最大增幅为53.95%。较阳性组，黄须菜干预组TC水平与其相近，TG效果不显著，而LDL-C值降低和HDL-C升高存在显著性差异（p<0.05）其中以高剂量组效果最为显著，LDL-C降低：43.07%，HDL-C升高：37.50%。可见黄须菜对高脂血症大鼠体质量、摄食量、肝重、附睾周脂重具有一定的预防及控制其增重的作用，并且对异常血脂有预防及降脂作用。

Abstract:

In order to provide a reference for using Suaeda sulsa in the prevention and treatment of hyperlipidemia, the effect of Suaeda sulsa on blood lipids in the rats with hyperlipidemia was investigated. Fifty-six male SD rats were randomly divided into seven groups: the normal group, Suaeda sulsa prevention group, high-fat model group, positive control group, and Suaeda sulsa high-dose, medium-dose and low-dose intervention groups. Except for the normal group and prevention group, the other groups were fed with a high-fat diet. During the experimental period, the normal group and the model group were given the same amount of distilled water via oral gavage. After 6 weeks of intervention, the body weight, food intake, liver weight, periepididymal fat weight and serum lipid levels were measured. Results showed that compared with the high-fat model group, the body weight, food intake, liver weight and periepididymal fat weight of the intervention group and the Suaeda sulsa prevention group decreased, with the largest decreases being 22.20%, 34.72%, 37.17% and 60.06%, respectively. In terms of blood lipids, compared with the high-fat model group, the intervention group and the prevention group had lower TC, TG and LDL-C values (with the maximum decreases being 33.58%, 54.27% and 65.26%, respectively), but higher HDL-C value (increase by 53.95%). Compared with the positive group, the intervention group had similar TC level, same TG level, but significantly (p< 0.05) lower LDL-C value and higher HDL-C value. In particular, the high dose group exhibited the most significant impact: decreased LDL-C by 43.07% and increased HDL-C by 37.50%. Accordingly, Suaeda sulsa can prevent and control the increases of body weight, food intake, liver weight and periepididymal fat weight in rats with hyperlipidemia, and also prevent and reduce the abnormal increase of blood lipids.