茯砖茶奶茶对高脂小鼠血脂水平的影响

Effect of Fuzhuan Milk Tea on Blood Lipid Level in High-fat Mice

摘要:

为探究茯砖茶奶茶对高脂饲料喂养小鼠血脂水平的影响。本实验选取126只雄性昆明小鼠，根据体重随机分成7组，即空白组、对照组、茶汤组、牛奶组、低剂量奶茶组（167 mg/kg）、中剂量奶茶组（834 mg/kg）、高剂量奶茶组（1667mg/kg）；通过对小鼠饲喂高脂饲料建立高脂模型，连续喂养28 d、35 d、42 d分析茯砖茶奶茶对高脂小鼠甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)四项指标的影响。结果表明：灌胃低、中、高剂量的茯砖茶奶茶与对照组相比，中剂量奶茶组能显著降低高脂小鼠的TC、TG、LDL-C含量（p<0.05），各指标下降比率分别为16.38%、66.67%、34.34%。在连续灌胃28 d、35 d、42 d，其中茶汤组在35 d时降脂效果显著，牛奶组无显著性差异变化，中剂量茯砖茶奶茶灌胃高脂小鼠在28 d时血脂呈最低水平。综上，茯砖茶奶茶具有显著降低血脂的作用，为进一步开发以茯砖茶为原料的产品提供了理论依据。

Abstract:

To investigate the effect of Fuzhuan Milk Tea on blood lipid level of mice fed with high fat diet. In this wok, 126 male kunming mice according to their body weight were selected, which were randomly divided into seven groups: blank group, control group, tea soup group, milk group, low (167 mg/kg), middle (834 mg/kg), high (1667 mg/kg) milk tea group. The mice model with hyperlipidemia was established by feeding a high-fat diet. At 28 th, 35 th, 42 th day of continuous gavage, serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol (LDL-C) of mice content were detected. The results showed that the contents of TC, TG and LDL-C in high-fat mice decreased significantly by intragastric administration of medium dose milk tea compared with the control group, which deceased by 16.38%, 66.67% and 34.34% respectively. Under the condition of continuous gavage for 28 days, 35 days and 42 days, the effect of reducing blood lipid in tea group was remarkable at 35 days, while the milk group was no significant difference. The lowest blood lipid level was observed at 28 days after gavage of high-fat mice with medium dosage of milk tea. In conclusion, Fuzhuan milk tea had a significant effect on reducing blood lipid, which could provide a theoretical basis for further development of products with Fuzhuan tea as raw material.