栀子醒酒饮品的醒酒及护肝作用

The Study of Anti-alcoholism Effect and Protecting Liver by Sober-up Drink of Gardenias in Temulentia Mice

摘要:

比较不同剂量栀子醒酒饮品对醉酒小鼠爬杆和转轮能力，肝肾病理切片，以及血液中谷草转氨酶(AST)、谷丙转氨酶(ALT)、肝脏中超氧化物歧化酶(SOD)、细胞色素P4502E1 (CYP2E1)含量的影响，以考察饮品对醉酒小鼠的醒酒及酒精性肝脏损伤小鼠的护肝作用。转轮结果显示，低、高剂量组掉落次数显著减少、第一次掉落时间增加(p<0.05)；爬杆结果显示，低、高剂量组爬杆等级显著降低、爬杆时间增加(p <0.05)。给药组能减少醉酒小鼠肝细胞脂肪性变，减轻肝脏细胞肿胀，缓解炎细胞浸润，减少小鼠肾小管水样性变；与模型组比较，低、中剂量组血液中AST值分别降低了33.13%、29.54%、ALT值分别减少了39.41%、38.91%，高剂量组肝内SOD含量增加了30.34%，给药组对CYP2E1影响较小，上述结果说明该醒酒饮品对醉酒小鼠的有一定的醒酒作用，并对小鼠的酒精性肝脏损伤有一定的保护作用。

Abstract:

In order to investigate the sobering effects of the different doses of sobering drinks and the protection of alcohol-induced liver injury on temulentia mice, the abilities of rods and runners, biochemical and histological examinations of blood, liver and kidney were compared . The results showed that the number of drops and level of climbing in low and high dose groups were less than those in model group (p<0.05), and the first drop time and climbing time were longer than those (p<0.05). Compared with model group, the vacuolar degeneration was reduced, the cell swelling and inflammation were lessened, and the renal tubular water degeneration of kidney was decreased in the drug-administered group. And the values of AST were diseased by 33.13% and 29.54%, as well as the values of ALT were reduced by 39.41% and 38.91% in low and middle dose groups. The content of SOD was increased by 30.34% in high dose group, and the administered groups had less influence on CYP2E1. The findings indicated that the sobering drink has a certain sobering effect on temulentia mice, and has certain protective effects on alcohol-induced live injury in mice.