普洱茶提取物及其复合配方改善糖尿病大鼠的糖脂代谢紊乱

Improvement of the Disorder of Glucose and Lipid Metabolism by Pu-Erh Tea Extract and the Compound Formula in Diabetic Rats

摘要:

本文观察了普洱茶提取物、玉米须提取物、低聚果糖及其复合配方对糖尿病模型大鼠糖脂代谢及胰岛素敏感性的影响。80只健康成年雄性SD大鼠随机分为8组：正常对照组给予普通饲料，模型对照组、普洱茶组、低聚果糖组、玉米须组以及低、中、高剂量复合配方组给予高脂饲料，受试物组经口灌胃给予6种受试物4周后，腹腔注射链脲佐菌素造模，继续给予受试物至实验结束。实验前后分别进行葡萄糖耐量试验，实验结束后测定各项指标。与模型对照组比较，普洱茶组大鼠体重、血清甘油三酯、肝脏胆固醇、肝脏甘油三酯、腹壁脂肪含量、脏体比、胰岛素抵抗指数分别降低了14.87%、77.59%、40.18%、39.18%、63.06%、55.81%和79.88%，但血糖和葡萄糖耐量无明显变化；低聚果糖组大鼠腹壁脂肪重量、脏体比、胰岛素抵抗指数分别降低了30.99%、29.46%和57.09%；玉米须组大鼠仅肝脏甘油三酯降低了36.06%；而三者复合配方能够显著降低大鼠的体重、体脂、血脂和肝脂水平，有效改善糖脂代谢紊乱和胰岛素抵抗。

Abstract:

The effects of Pu-erh tea extract, stigma maydis extract, oligofructose and their compound formula on glucose and lipid metabolism and insulin sensitivity in diabetic rats were investigated in this study. Eighty healthy adult male Sprague Dawley rats were randomly divided into 8 groups: The normal control group was given normal chow diet, the model control group, Pu'er tea group, oligofructose group, stigma maydis group and low, medium and high doses of compound formula groups were fed with high-fat diet. The treatment groups were given 6 test substances respectively by oral administration for 4 weeks, then, were intraperitoneally injected with Streptozocin to establish the model. And the test substances were continued until the end of the experiment. Glucose tolerance test was carried out at the beginning and the end of the experiment. Various indicators were measured after the experiment. Compared with the model control group, body weight, serum triglyceride, liver cholesterol, liver triglyceride, abdominal fat weight, organ coefficient and insulin resistance index in Pu'er tea group were reduced by 14.87%, 77.59%, 40.18%, 39.18%, 63.06%, 55.81% and79.88%, respectively, but had no significant effect on serum glucose and glucose tolerance. In the oligofructose group, the abdominal fat weight, organ coefficient, and the insulin resistance index decreased by 30.99%, 29.46% and 57.09%, respectively. In the stigma maydis group, only the liver triglyceride decreased by 36.06%.The compound formula significantly reduced body weight, body fat, serum lipids and hepatic lipid levels, and improved glucose and lipids dysmetabolism and insulin resistance effectively in STZ-induced diabetic rats.