红砖茶的降血脂及抗氧化活性研究

Auxiliary Hypolipidemic and Antioxidative Activity of Hongzhuan Tea

摘要:

为探讨红砖茶辅助降血脂功效，本研究参照《辅助降血脂功能评价方法》中动物实验方法，以高脂血症大鼠为对象，灌胃红砖茶水提物[低、中、高剂量分别为88.75、177.50、355.00 mg/(kg·d)]，检测相关指标。结果表明：3个红砖茶水提物剂量组与模型对照组相比，血清TG浓度，中、高剂量组极显著降低(p<0.01)，低剂量组无显著差异；血清TC浓度，3个剂量组均无显著差异；血清中HDL-C浓度，中剂量组显著升高(p<0.05)，低、高剂量组无显著差异；血清中LDL-C浓度，高剂量组显著降低(p<0.05)，低、中剂量组无显著差异。根据判定规则，提示红砖茶水提物辅助降低血脂功能动物实验结果阳性；辅助降低血清胆固醇功能动物实验结果阳性；辅助降低血清甘油三酯功能动物实验结果阳性。中、高剂量组红砖茶水提物同时可以显著提高血脂大鼠肝匀浆中超氧化物歧化酶（SOD）(p<0.05)及谷胱甘肽过氧化物酶（GSH-PX）(p<0.01)浓度，降低丙二醛(MDA) (p<0.05)浓度，提示其具有一定抗氧化功效。

Abstract:

The aim of the study was to investigate the auxiliary hypolipidemic and antioxidative activity of the Hongzhuan tea. According as the animal experimental methods from , the related indicatorsin hyperlipidemia rats were tested after the rats were given by oral administrations of Hongzhuan tea aqueous extracts with different doses of 88.75 mg/(kg·d), 177.5 mg/(kg?d) and 355 mg/(kg?d). The results showed that the serum TG was significantly reduced in rats treated with medium and high dose groups(p<0.01), while the low dose group had no significant difference compared with the control group. The serum total cholesterol (TC) in the three groups had no significant difference. The serum high-density lipoprotein cholesterol (HDL-C) significantly increased in rats administrated with medium dose group (p<0.05), but had no significant difference in low and high dose groups. The serum low-density lipoprotein cholesterol (LDL-C) was significantly reduced in rats administrated with high dose group (p<0.05), but had no significant difference in low and medium dose groups. According to the judging rules, the results showed that the Hongzhuan tea aqueous extracts assisted hypolipidemic function, reducing serum cholesterol function, and reducing serum triglyceride were positive the animal experiment. The activities of SOD (p<0.05) and GSH-Px (p<0.01) in liver were significantly increased in medium and high dose groups, while the concentration of MDA (p<0.05) was significantly reduced which showed that its antioxidative activity was positive.