Abstract:This study aimed to investigate the effect of mulberry leaf and balsam spear mixed powder on blood lipid metabolism in diabetic mice, and provide a reference for the development and utilization of healthy food with hypoglycemic and antidiabetic activities. A mouse model of diabetes mellitus was established, and the animals were fed a basal or high-fat diet along with different doses of mulberry leaf and balsam spear mixed powder. Blood samples were collected 30 d later to measure changes in the serum biochemical indices related to lipid metabolism in the mice. The results showed that when the mice were fed 0.5 ml of 0.20 g/mL mulberry leaf and balsam spear mixed powder solution, the levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in the diabetic mice fed with basal or high-fat diets were significantly lower than those in the control group (p<0.05). In addition, the high-density lipoprotein cholesterol (HDL-C) levels were significantly higher than that of the control group. For female and male mice fed the basal diet, LDL-C values decreased by 57.14% and 57.41%, respectively; HDL-C values increased by 96.97% and 95.45%, respectively; TC values decreased by 14.58% and 18.45%, respectively; and TG values decreased by 20.57% and 21.98%, respectively. All values of blood lipid indicators tended to be close to normal values. Therefore, the intake of mulberry leaves-bitter gourd mixed powder with diet control can have a beneficial hypolipidemic effect in diabetic mice.
