Abstract:The possible hypoglycemic effects of mulberry leaf-balsam pear mixed powder fed to diabetic mice were investigated to provide a reference for the development of healthy foods for patients with diabetes. After a mouse model of diabetes was successfully created by intraperitoneal injection of alloxan, the mice were divided into six groups: one model group, four groups receiving different doses of mulberry leaf-balsam pear mixed powder, and a positive control group (metformin); an untreated control group was also included. The mice were fed basal feed and mulberry leaf-balsam pear mixed powder, and the body weight, glucose tolerance, liver glycogen content, and changes of blood glucose were measured. The results show that compared with model group, female and male diabetic mice that were fed 0.20 g/mL 3:1 mulberry leaf-balsam pear mixed powder and basal feed for 30 d experienced an inhibition of weight loss, and the inhibition rates reached 69.44% and 70.00%, respectively. For female and male mice, the blood glucose levels were decreased by 45.8% and 42.99%, respectively, the areas under the blood glucose time curve (AUC) were decreased by 29.77% and 29.54%, respectively, and liver glycogen levels were increased by 1.42 and 1.50 times, respectively. With dietary control, an intake of a certain dose of mulberry leaf-balsam pear mixed powder can exert a good auxiliary hypoglycemic effect on diabetic mice.
