微波固相合成技术及其在多肽（氨基酸）金属螯合物合成中的应用

Microwave Solid-phase Synthesis Technique and Its Application in the Synthesis of Polypeptide (Amino Acid)-Metal Chelates

摘要:

多肽（氨基酸）金属螯合物是一种新型金属营养补充剂，具有吸收利用率高，代谢过程能耗低，转运速度快和不易被饱和等优点，而且多肽可作为金属元素配体通过小肽转运系统进入肠黏膜细胞，稳定性高，并可减少金属间拮抗作用，具有很好的应用前景。微波固相合成技术作为一种新型多肽（氨基酸）金属螯合技术，相比传统液相合成法，具有反应速度快、反应效率高、能耗低、工艺操作简单、污染少和无废液产生等优点，广泛应用于多肽（氨基酸）金属配位螯合物的合成中。本文从微波固相合成的机理、影响因素、金属螯合物鉴别及其在多肽（氨基酸）金属螯合物合成中的应用等方面进行了系统综述，并对微波固相合成技术的应用提出了一些建议，以期为微波固相合成技术在多肽（氨基酸）金属螯合物合成中的应用起到良好的推动作用。

Abstract:

Polypeptide (amino acid)-metal chelates are a new-type metal nutritional supplement with the advantages of high absorption and utilization ratios, low energy consumption during metabolism, and fast transport speed, as well as their inability to be easily saturated. Additionally, polypeptides can serve as metal element ligands to enter intestinal mucosal cells through small peptide transport systems. Polypeptide (amino acid)-metal chelates are highly stable and can reduce the antagonism among metal ions, showing good application prospects. Compared to traditional liquid-phase synthesis, microwave solid-phase synthesis is a new polypeptide (amino acid)-metal complex synthesis technique with the advantages of fast reaction rate, high reaction efficiency, low energy consumption, simple process operation, low level of pollution, and no waste liquid production, and has been utilized widely in the synthesis of polypeptide (amino acid)-metal chelates. In this paper, the principles, applications, and factors affecting microwave solid-phase synthesis of polypeptide (amino acid)-metal chelates and their identification were systematically reviewed. Meanwhile, some suggestions for the development of microwave solid-phase synthesis technique were made, in order to promote the application of the technique in the synthesis of polypeptide (amino acid)-mental chelates.