Abstract:In order to explore the hepatoprotective effects of Fructus mori Polysaccharide (FMP) on mice with acute and chronic alcoholism. Inebriation time, blood alcohol concentration, liver function enzymes, oxidase, oxidation products, and fat distribution in the liver were measured in mice with acute alcoholism after continuous FMP administration for 4 weeks. The number of spontaneous activities, serum lipids, apolipoproteins, nitric oxide (NO), and cytokine content in the liver were measured or observed in mice with chronic alcoholism after continuous FMP administration for 10 weeks. The results showed that high and moderate doses of FMP (400 and 200 mg/kg bw) significantly reduced inebriated sleep time, sobering time, and blood alcohol concentration, and significantly extended inebriation latency in mice with acute alcoholism. Malondialdehyde (MDA) and triglyceride (TG) contents and the distribution of lipid droplets in the liver were significantly decreased upon FMP administration at these doses. In addition, reduced glutathione (GSH) content and superoxide dismutase (SOD) activity were significantly increased, and the activity of alanine transaminase (ALT), aspartate aminotransferase (AST), serum alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT) in serum were significantly reduced. FMP significantly reduced spontaneous activity, the content of cholesterol (TC), TG, blood low-density lipoprotein (LDL), NO content, and tumor necrosis factor-α (TNF-α) level in livers of mice with chronic alcoholism. Serum high density lipoprotein (HDL) and interleukin-10 (IL-10) in the liver were significantly increased. Fructus mori polysaccharide had a significant hepatoprotective effect on mice with acute and chronic alcoholism.
