香蕉粉对Ⅱ型糖尿病模型大鼠血糖及胰岛素抵抗的影响

Effects of Banana Powder on Blood Glucose and Insulin Resistance in a Rat Model of Type II Diabetes Mellitus

摘要:

本文研究了香蕉粉对链脲佐菌素（STZ）所致Ⅱ型糖尿病大鼠血糖及胰岛素抵抗的影响。将SD大鼠分为：糖尿病模型组（DCG）、糖尿病大鼠香蕉粉干预组（DBG）、正常对照组（NCG）、正常大鼠香蕉粉干预组（NBG），用香蕉粉干预大鼠 8周，结果显示：与DCG组相比，DBG组大鼠空腹血糖显著降低，降低了32.75%，糖耐量状况得到显著改善，体重显著增加，增加了7.92%；DBG组大鼠的血清总胆固醇、甘油三酯、低密度脂蛋白及游离脂肪酸水平显著降低，分别降低了50.65%、79.63%、60.38%和39.71%；高密度脂蛋白/总胆固醇的比值显著提高，提高了86.96%，血脂恢复到正常大鼠水平；DBG组大鼠的血浆胰岛素水平显著降低，胰岛素抵抗指数降低51.28%，胰岛素敏感指数提高14.87%，胰岛β细胞功能提高38.31%。研究表明，香蕉粉有一定的血糖调节功能，能缓解糖尿病造成的体重下降问题，并有效改善糖尿病大鼠的脂代谢紊乱及胰岛素抵抗。

Abstract:

The effect of banana powder on blood glucose and insulin resistance in streptozotocin-induced type II diabetic rats was studied. Sprague-Dawley (SD) rats were divided into normal control group (NCG), diabetic control group (DCG), diabetic group with banana powder intervention (DBG), and normal group with banana powder intervention (NBG). After eight weeks of intervention, the fasting blood glucose of DBG rats was reduced by 32.75%, their glucose tolerance improved, and their weight was increased by 7.92% (all when compared with DCG rats). DBG rats also showed dramatic decreases in total cholesterol, triglyceride ester, free fatty acids, and low-density lipoprotein by 50.65%, 79.63%, 60.38% and 39.71%, respectively; as well as an 86.96% increase in the ratio of high-density lipoprotein:total cholesterol, and a normalization of blood lipid content (all in comparison to those of DCG rats). Further, compared with DCG rats, the plasma insulin and insulin resistance index of DBG rats were significantly reduced by 25.18% and 51.28%, respectively, and the insulin sensitivity index and pancreatic β-cell function of DBG rats were increased by 14.87% and 38.31%, respectively. This study indicates that banana powder shows a certain capability to regulate blood glucose, mitigate weight loss, and effectively improve lipid metabolism disorder and insulin resistance in diabetic rats.