研究了玉米须黄酮提取物对尿酸钠所致大鼠痛风性关节炎的影响。给药组大鼠灌胃给予玉米须黄酮提取物（1 g/kg、0.5 g/kg、0.25 g/kg），连续8天，空白及模型对照组灌胃给予等体积蒸馏水，第5天灌胃1小时后于模型及给药组大鼠右踝关节腔内注射尿酸钠溶液2.5 mg/mL，诱导痛风性关节炎的发生，72小时后测定大鼠踝关节肿胀度及血浆中白细胞介素1α（IL-1α）、白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、细胞间粘附分子1（ICAM-1）及基质金属蛋白酶1（MMP-1）的水平，并进行大鼠右踝关节病理组织学检查。与模型对照组比较，给予玉米须黄酮提取物后，其高、中剂量组（1 g/kg、0.5 g/kg）的踝关节肿胀度均明显降低（P<0.01），血浆IL-1α、IL-6、TNF-α及血浆ICAM-1、MMP-1水平明显降低（P<0.05），并且可以改善造模大鼠关节滑膜组织的病理改变。提示玉米须黄酮提取物具有较好的抗痛风性关节炎的作用。

The effect of flavonoids extracted from corn (Stigma Maydis) silk (FESM) on gouty arthritic rats was determined in this study. Rats in the treatment group were treated with different quantities of FESM (1, 0.5, and 0.25 g/kg) via gavage for 8 days; rats in the control and model groups were treated with the same amount of distilled water. On the fifth day, rats from the treatment and model groups were injected with sodium urate (2.5 mg/mL) in the right ankle joint cavity one hour after gavage, in order to induce gouty arthritis. The extent of swelling in the right ankle joint, and plasma interleukin 1α (IL-1α), IL-6, tumor necrosis factor-α (TNF-α), intercellular adhesion molecule 1 (ICAM-1), and matrix metalloproteinase-1 (MMP-1) contents were measured after 72 hours. The right ankle joint was also subjected to an histopathological examination. Rats belonging to the groups treated with high and moderate doses of FESM (1 and 0.5 g/kg) displayed significantly lower right ankle joint swelling (P < 0.01) and plasma IL-1α, IL-6, TNF-α, ICAM-1, and MMP-1 content (P < 0.05), compared to the rats in the control group. Therefore, FESM was believed to improve the degree of pathomorphological changes in the synovial tissue of the joints. These results indicated the beneficial effect of FESM on gouty arthritis.

国家科技重大专项课题（2009ZX09103-348）；吉林省自然科学基金项目（201115166）；吉林省中医药科研重点项目（2011-zd03）