研究了一种采用N-辛基吡啶六氟硝磷酸盐（n-octylpyridinum hexa?uorophosphate，OPFP）离子液体为电极粘合剂和石墨烯（graphene，GR）纳米材料为电极表面修饰剂的新型丝网印刷电极（GR-ILSPE），用于检测药品中芦丁的含量。该新型电极结合了丝网印刷电极制作成本的低廉，离子液体在室温下优良的离子导电性、粘合性和电化学稳定性，以及石墨烯大的比表面积、高的电子传递和强的催化性能，极大的提高了电极的实用价值和电化学性能。并通过循环伏安法、阻抗谱和差脉冲伏安法等电化学方法研究了芦丁在GR-ILSPE的电化学行为，优化了检测参数。在最佳检测条件下，芦丁的浓度在5×10-8~5.5×10-6 mol/L与其对应的氧化峰电流呈现良好的线性关系，检测下限为2.5×10-8 mol/L，线性回归方程为I(μA)=1.01C(μmol/L)-0.024，线性相关系数0.999。将该新型的丝网印刷电极用于检测药片中芦丁的含量，表现出良好的选择性和高的稳定性。

In this paper, a novel screen-sprinted electrode (GR-ILSPE) modified by n-octylpyridinum hexa?uorophosphate (OPFP) and graphene (GR) was fabricated and used for sensitive detection of rutin in medicine. The novel screen-sprinted electrode produced with low costs combined with good advantages of ionic conductivity, adhesiveness and electrochemical stability that existed at room temperature, and also with good performances of the large specific surface area, high electron transfer and catalytic ability of graphene that greatly enhanced the practical value and electrochemical properties. Different electrochemical methods such as cyclic vohammetry, impedance spectroscopy and differential pulse voltammetry were used to investigate the electrochemical behaviors of rutin on GR-ILSPE, and the electrochemical parameters were optimized. Under the optimal conditions, the oxidative peak current was linearly related to its concentration in the range from 5×10-8 to 5.5×10-6 mol/L with the detection limit estimated to 2.5×10-8 mol/L, and the linear regression equation was I (μA)= 1.01C(μmol/L) -0.024 (r=0.99). Finally, the developed electrode was successfully applied to detect the content of rutin in tablet, which displayed excellent selectivity and good stability.

高等学校博士学科点专项科研基金项目（20120008110033）