青钱柳多糖对高脂血症大鼠血脂及抗脂质过氧化作用的影响

Effect of Cyclocarya paliurus Polysaccharide on Hyperlipidemia and Anti-lipid Peroxidation in Hyperlipidemic Rats

摘要:

为研究青钱柳多糖（Cyclocarya paliurus (Batal.) Iljinskaja polysaccharide，CPP）对高脂血症大鼠脂类代谢及抗脂质过氧化作用的影响，将高脂血症大鼠分为高脂血症模型组、辛伐他汀组、青钱柳多糖高、中、低剂量组，每组16只，连续喂养8周。实验结束后测定血清TG、TC、LDL-C和HDL-C，同时测定血清及肝脏组织中T-SOD、GSH-Px、CAT、T-AOC及MDA含量。结果表明，与高脂模型组相比，CPP低、中、高剂量组可显著降低高脂血症大鼠的血清TC、TG、LDL-C，MDA含量（P<0.01），其最大降幅分别为29.17%、50.00%、57.25%和25.72%；低、中、高剂量多糖均可显著提高血清HDL-C含量和T-SOD、GSH-Px、T-AOC活性（p<0.01），其最大增幅分别为72.22%、16.27%、16.38%和59.43%。结果提示青钱柳多糖对实验性高脂血症模型大鼠具有降血脂、抗脂质过氧化作用，以高剂量（800 mg/kg）效果为最佳。

Abstract:

The hyperlipidemic rats were randomly divided into model control, simvastatin, Cyclocarya paliurus polysaccharides (CPP) low dose, middle dose, high dose groups (16 rats per group). After 8 weeks treatments, the levels of TC, TG, HDL-C, LDL-C, T-SOD, GSH-Px, CAT, T-AOC and MDA were measured. The results showed that CPP decreased serum TC, TG, LDL-C, MDA remarkably (P <0.01) with the decreasing rate of 29.17%, 50.00%, 57.25% and 25.72% respectively, while increased the levels of HDL, T-SOD , GSH-Px and T-AOC (P<0.01) with the highest growing rates of 72.22%, 16.27%, 16.38% and 59.43%. It was indicated that CPP could regulate lipid metabolism, enhance the anti-oxidation and reduce the lipid peroxidation in rats with hyperlipidemia.