化州橘红多糖对小鼠消炎、止咳及化痰功效的影响研究

Dephlogisticate, Antitussive and Expectorant Effects of Polysaccharides from Exocarpium citri grandis on Mice

摘要:

本试验研究了化州橘红多糖的消炎、止咳、化痰作用。采用二甲苯耳廓肿胀致炎法来观察化州橘红多糖对小鼠的消炎作用；小鼠浓氨水引咳法来观察化州橘红多糖的止咳作用；小鼠气管段酚红排泌法观察化州橘红多糖的化痰作用。化州橘红多糖对二甲苯引起的小鼠耳廓肿胀有不同程度的抑制作用，其中化州橘红多糖低、中、高剂量组的肿胀抑制率分别为24.93%、34.84%和48.72%，阿司匹林阳性对照组的肿胀抑制率为52.83%；化州橘红多糖能明显的延长浓氨水刺激引起的小鼠的咳嗽潜伏期及减少2 min内的咳嗽次数，其中化州橘红多糖高剂量组的效果好于磷酸苯丙哌林片阳性对照组；化痰试验显示化州橘红多糖中、高剂量组与空白对照组之间存在极显著性差异（P<0.01），低剂量组差异不明显，即化州橘红多糖能够增加小鼠气管段酚红的排泌量。结果表明化州橘红多糖具有较好的消炎、止咳及化痰作用。

Abstract:

The dephlogisticate ,antitussive and expectorant effects of the polysaccharides from Exocarpium citri grandis (ECP) were studied. The models of edema induced by xylene, cough induced by concentrated ammonia water and phenel red execretion in mice were used to observe the dephlogisticate effect, the antitussive effect and the expectorant effect, respectively. Result showed that ECP could inhibit the edema induced by xylene in mice. The swelling inhibition rates in low, middle and high dose group were 24.93%, 34.84% and 48.72%, respectively. The swelling inhibition rate in the positive control group was 52.83%. It was also found that ECP could prolong cough incubation period and reduce the cough times in 2 minutes induced by concentrated ammonia water. There was a significant difference (P < 0.01) between the control group and the middle/high dose groups, which meant that the ECP could increase phenel red execretion in mice. ECP showed a significant dephlogisticate, antitussive and expectorant effects.