茵陈黄酮的抗氧化及镇痛作用研究

Antioxidant and Analgesia Activities of Flavonoids from the Capillary artemisia

摘要:

对茵陈黄酮体外抗氧化活性及对小鼠致痛作用的抑制研究表明，与Vc相比，在体外实验中，茵陈黄酮粗提物和茵陈黄酮纯化物对?OH基和DPPH自由基具有良好的清除能力，对花生油氧化有明显的抑制效果，在小鼠体内实验中，茵陈黄酮黄酮粗提物和纯化物可显著降低由腹腔注射醋酸引起的小鼠扭体次数，茵陈黄酮纯化物对小鼠小鼠扭体反应的抑制力达到60.67%，同时也可减少热刺激和甲醛诱导的小鼠舔足次数，说明茵陈黄酮对化学物质和炎症引起的疼痛均具有一定的缓解作用。茵陈黄酮抗氧化及镇痛活性显著。

Abstract:

The antioxidant and analgesia activities of flavonoids from Capillary artemisia were studied. The results showed that the flavonoids from the Capillary artemisia had obvious scavenging activity in vitro against OH and DPPH free radicals and showed obvious inhibiting effects on peanut oil oxidation. In vivo experiments showed that the flavonoid from the Capillary artemisia resulted in a notable decrease in acetic acid-induced writhing number and feet-licking number induced by heat or formaldehyde, indicating that it had alleviating effect on pain in mice induced by chemicals and inflammatory reaction. The flavonoids from Capillary artemisia have obvious antioxidant and analgesic activities.