辅酶Q10、番茄红素单独以及联合补充对大鼠运动能力的影响

Effects of Coenzyme-Q10/Lycopene Single or Combination on Exercise Capacity of Rats

摘要:

为观察辅酶Q10、番茄红素单独以及联合补充对大鼠的运动能力以及抗疲劳作用的影响；采用灌胃方法，各组持续给予受试物4 周。4周后进行力竭游泳时间、力竭恢复24 h后测试肝脏/股四头肌的超氧化物歧化酶SOD、丙二醛MDA水平；血清乳酸脱氢酶LDH、肌酸激酶CK等各项指标。结果表明，补充辅酶Q10、番茄红素均能延长大鼠力竭游泳时间（P<0.05）,联合使用具有极显著性差异（P<0.01）；给药组肝脏组织超氧化物歧化酶SOD酶活有明显提高，其中联合组（P<0.01），Q10组（P<0.05）；联合组的肝脏组织、肌肉组织以及Q10组的肝脏组织的丙二醛MDA水平有显著性降低（P<0.05）。联合组的血清乳酸脱氢酶LDH、肌酸激酶CK酶活均有明显降低(P<0.01)，Q10组LDH (P<0.05)，Q10组CK (P<0.01)，番茄红素组CK(P<0.05)。辅酶Q10、番茄红素具有提高大鼠运动能力，促进剧烈运动后疲劳恢复，联合使用具有协同作用。

Abstract:

This paper studied the effect of coenzyme Q10/lycopene alone or their combination on the exercise performance of induced fatigue rats. 48 rats were randomized into 4 groups. After 4 weeks of consecutive administration with the materials tested by gastric perfusion method, exhaustive swimming time was tested. After 24 hours rest, the SOD, MDA of liver/muscle tissues and the enzyme activity of CK/LDH in blood of each group were analyzed. Result showed that, compared with control group, coenzyme Q10/lycopene alone(P<0.05) or their combination（P<0.01) can prolong exhaustive swimming time. A significant decrease of MDA content in liver and muscle tissue was observed in mice administered combination group (P<0.05), and MDA reduction in liver of Q10 alone group was also observed (P<0.05). SOD activity in liver tissues revealed an obvious increase in mice with combined administration (P<0.01) and Q10 group (P<0.05) . The activity of LDH in blood exhibited a significant amelioration in mice with Q10 single(P<0.05) or combined administration (P<0.01). The CK in blood also got better result in mice with individual administration of Q10 (P<0.01) or lycopene (P<0.05), or combined administration(P<0.01). The result showed that individual administration of coenzyme-Q10 and lycopene can enhance the endurance of rats and improve the anti-oxidation capability. A synergistic effect among them is also achieved.