山莓叶醇提物对不同模型小鼠腹泻的影响

Effects of Ethanol Extracts from Rubus Corchorifolius Leaves on Different Models of Mice Diarrhea

摘要:

本文研究了山莓叶醇提物（RE）对四种不同类型小鼠腹泻的影响。采用番泻叶、蓖麻油、硫酸镁、致泻大肠埃希氏菌建立不同小鼠腹泻模型，分别设置空白对照组（BC）、模型组（MC）、阳性药物组、山莓叶醇提物高（RH）、中（RM）、低剂量组（RL）6个组，观察稀便数、稀便级，计算腹泻指数。结果表明，与MC相比，RE对抗番泻叶所致小鼠腹泻0~3 h内的腹泻指数均极显著降低（P<0.01）；RH和RM对抗蓖麻油所致小鼠腹泻0~5 h内的腹泻指数均显著降低（P<0.05）；RM对抗大肠埃希氏菌所致小鼠腹泻0~2 h内的腹泻指数极显著降低（P<0.01）；RM和RH对抗硫酸镁所致小鼠腹泻指数均仅在0~1 h内明显降低（P<0.01）。山莓叶醇提物对番泻叶、蓖麻油和致泻大肠埃希氏菌导致的小鼠腹泻有显著抑制作用，对硫酸镁所致腹泻的干预作用较弱。

Abstract:

To study the effects of ethanol extracts from Rubus corchorifolius L.f leaves (RE) on four different models of mice diarrhea， different models of mice diarrhea were induced by senna, castor oil, magnesium sulfate and Escherichia coli, and six groups were set up, including blank control group (BC), model control group (MC), positive drug control group, high/middle/low dosage of RE(RH, RM, RL). The indexes of amounts of loose stools and the level of loose stools were observed and the diarrhea index was calculated. Compared with MC group, the diarrhea index of RE groups induced by senna was reduced significantly during 0~3 h (P<0.01); the diarrhea index of RH and RM groups induced by castor oil was reduced significantly during 0~5 h (P<0.05). The diarrhea index of RM group induced by Escherichia coli was reduced significantly during 0~2 h (P<0.01). The diarrhea index of RH and RM groups induced by magnesium sulfate was reduced significantly just during 0~1 h (P<0.01). There were significantly induction of RE on the diarrheal models induced by senna, castor oil, and Escherichia coli, while weak effect on the magnesium sulfate one.