Borojo果酶解浓缩粉的毒理学安全性评价

Toxicological Evaluation of Enzymatically-Hydrolyzed Borojoa Concentrated Powder

摘要:

本文通过动物实验，研究Borojo 果酶解浓缩粉的食用安全性。采用急性毒性试验、小鼠骨髓微核试验、小鼠精子畸形试验及大鼠30天喂养试验对Borojoa果酶解浓缩粉进行评价。结果表明，雌雄小鼠经口急性毒性LD50＞21.5 g/kg?bw，根据急性毒性分级，受试物Borojo 果酶解浓缩粉属无毒级物质；小鼠骨髓微核试验、小鼠精子畸形试验结果与对照组比较均无显著性差异；大鼠30d喂养试验表明各剂量组动物体重增重、食物利用率、脏体比、血液学检查及血液生化检查与对照组比较均无显著性差异；病理检查主要脏器未见明显中毒性病理改变，说明Borojo果酶解浓缩粉属于安全性食品。

Abstract:

The safety of enzymatically treated Borojo concentrated powder was evaluated through animal experiments, including acute toxicity test, mouse bone marrow micronucleus test, sperm shape abnormality test in mice and 30-day feeding study. Results showed that the oral acute toxicity LD50 of male and female mice was above 21.5g/kg?bw. Enzymatically treated Borojo concentrated powder was nontoxic substances based on the acute toxicity grading. The mouse bone marrow micronucleus test and mouse sperm abnormality test results showed no significant differences with the control group. The 30-day feeding study in rats showed that the weight gain, food utilization, the ratio of dirty and body, hematologic and blood biochemical index of the animals in each dose group had no significant differences with the control group. The pathological examination showed little obvious toxic pathological changes in major organs. The enzyamtically treated Borojo concentrated powder was considered as a safe food.