考察了重金属铅、砷对蝙蝠蛾拟青霉菌丝体发酵的影响，结果表明铅对菌丝体的生长以及其有效成分含量的影响较小，而砷对蝙蝠蛾拟青霉具有较强的细胞毒性，当培养基砷浓度为100 μg/kg时，多糖和甘露醇的总产量分别下降了28%和14%。培养基中铅、砷离子浓度在0~100 μg/kg范围内，菌丝体中铅、砷离子浓度与培养基中铅、砷离子浓度的关系分别满足线性方程和罗杰斯特方程。

The influence of plumbum and arsenic on the submerged fermentation with paecilomyces hepialid has been investigated. The results showed that plumbum had little effect on the fermentation with paecilomyces hepialid, but arsenic showed high cell toxicity during the fermentation. When the arsenic concentration was 100 μg/kg, the yields of polysaccharide and mannitol decreased by 28% and 14%, respectively. When plumbum and arsenic concentrations were in range of 0~100 μg/kg, the curves described by the lead and arsenic concentration in the mycelia and the culture medium fitted well to linear equation and logistic equation, respectively.