以正常动物小鼠为实验对象，分别在给药第1 d后30 min及连续给药7 d后30 min灌胃服用淀粉、蔗糖和葡萄糖；分别测定不同糖原对血糖生成指数、胰岛素水平和对α-葡萄糖苷酶活性的抑制率，对鲜罗汉果皂苷调节血糖药效学进行了研究。结果表明：一次性服用鲜罗汉果皂苷对多糖类食物淀粉和蔗糖的血糖生成有显著的抑制作用；但单次给药对葡萄糖的血糖生成没有明显影响；连续7 d服用鲜罗汉果皂苷后，淀粉及葡萄糖的血糖生成均受抑制，血糖峰值或血糖生成指数(GI)显著下降；进食鲜罗汉果皂苷在餐后血糖升高时的胰岛素水平显著增加，对α-葡萄糖苷酶活性抑制作用随浓度增加而增强。故鲜罗汉果皂苷对正常小鼠餐后血糖生成有显著的抑制作用，通过抑制食物葡萄糖转化和提高胰岛素水平是调节降低血糖的主要原因；与干罗汉果皂苷对比，提高餐后胰岛素水平作用鲜罗汉果皂苷比干罗汉果皂苷更显著，而对α-葡萄糖苷酶活性抑制作用干罗汉果皂苷要比鲜罗汉果皂苷强。

To study blood sugar regulation effect of Fresh Mangosteen Saponins (FMS), normal mice were orally administrated with FMS for one day or seven days. At 30 min after, intragastric administration with starch, sucrose or glucose respectively, Glycemic index (GI), insulin concentration and inhibition rate of α-glucosidase were determined. Result showed that single dosage of FMS inhibited GI of tarch and sucrose significantly, but had no effect on GI of glucose. After 7 days administration of FMS, GI of both tarch and glucose were inhibited, GI and the peak value of blood glucose are reduced. FMS administration increased postprandial insulin concentration significantly, and FMS dose-dependently inhibited α-glucosidase activity. It was concluded that FMS produced significant inhibition of postprandial blood glucose in normal mice, this effect is mediated primarily by inhibition of food glucose transformation and insulin increasing. When compared with the dry mangosteen saponin, FMS demonstrated higher insulin-increasing effect than dry mangosteen saponin, while the α-glucosidase inhibitory activity was weaker.

国家星火计划项目（2006EA790008）