茶多糖及协同因子的降血糖作用研究

Research of Hypoglycemic Effects of Tea Polysaccharide and Synergy Factors

摘要:

通过对小鼠喂以高脂，高糖饲料，腹腔注射四氧嘧啶的方式建立高血糖小鼠模型。研究茶多糖及其协同因子的降血糖作用，在实验的0 d，30 d时，眼底静脉丛取血，测其血糖浓度。实验结束时，取其脾脏及胸腺称重，并把肝脏制成10%的肝匀浆，测定肝组织肝糖元、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性和丙二醛（MDA）水平。结果表明：茶多糖及协同因子茶多酚能降低高血糖小鼠的血糖，可提高高血糖小鼠的脾指数及胸腺指数，提高高血糖小鼠抗氧化能力，使血糖进入肝细胞，使肝糖元合成增加，葡萄糖氧化分解加快，达到调节糖代谢、降低血糖的作用。

Abstract:

The hypoglycemic effects of tea polysaccharide and synergy factors were studied. Diabetic mice were modeled based on a high-fat and high-sugar feed and injected with alloxan. Fasting blood glucose was determined on day 0 and 30. The blood samples of mice were taken through ophthalmoscopy vein plexus. At the end of experiment, the spleen and thymus were taken to weigh, and the liver was made of 10% liver homogenate, the liver glycogen, pyruvate kinase (PK), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) level in the liver issue were measured. The results showed that tea polysaccharide and synergy factor can reduce high blood glucose levels of diabetic mice and improve the spleen and thymus index of high blood glucose mice. TPS an TP can improve their high antioxidant capacity, make blood sugar into the liver cell, enhance the synthesis of glycogen yuan and the oxidative degradation of glucose, thus adjusting sugar metabolism and reducing blood sugar.