Abstract:Penicillium was screened for the degradation of camellia saponin . The optimal condition for Penicillium culture and camellia saponin degradation was determined through single factor test and L9(34)orthogonal test. The best culture conditions were: culture temperature 28 ℃, inoculation dose 12%, pH 4.5, and Penicillium cultivating time 5 days. Under these condition degradation rate of camellia saponin could reached 83.11%.