Abstract:The ultrasonic extraction of flavone from persimmon leaves was studied in this article. By orthogonal experiment, the optimal extraction conditions were obtained as follows: liquid-solid ratio of 50:1, ethanol concentration of 60%, ultrasonic power of 250 W, extraction time of 45 min and extraction times of twice, under which the extraction rate was above 90% and the average content of flavone in persimmon leaves was 2.59%.