苦参总碱对小鼠体内抗肿瘤作用的研究

Experimental Studies on the Anticancer Effect by Alkaloids form Sophora flavescens

摘要:

研究了苦参总碱的体内抗肿瘤作用。通过苦参总碱对荷S180肉瘤和H22肝癌小鼠的瘤重和生存时间影响的研究，观察了苦参总碱的小鼠体内抗肿瘤作用。结果表明：苦参总碱剂量中生药含量在8 g/kg以上能抑制荷S180和H22小鼠瘤体的生长，其抑制率可达30%，从而延长荷瘤小鼠的生存时间，表明苦参总碱具有明显的抗肿瘤作用。

Abstract:

Antitumor effects of Alkaloids from Sophora flavescens on weight and survival time of S180 and H22 -bearing mice in vitro were studied. The results showed that alkaloids from Sophora flavescens could inhibit the growth of cancer cells of S180-bearing mice and prolong the survival time of H22 -bearing mice.