研究古尼虫草多糖的抗衰老作用。将健康小鼠随机分为空白组、模型组、低剂量组、中剂量组和高剂量组，将模型组、低剂量组、中剂量组和高剂量组用D-半乳糖造亚急性衰老小鼠模型；低剂量组、中剂量组和高剂量组的小鼠建模11 d后每天灌胃50%古尼虫草多糖溶液，剂量分别为100 mg/kg、200 mg/kg和400 mg/kg；45 d后观察脑组织中以及血清中超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活力，丙二醛（MDA）含量。结果表明，古尼虫草多糖可提高小鼠脑组织和血清中SOD（p＜0.01）GSH-Px（p＜0.01）活力，明显抑制小鼠脑组织和血清中MDA（p＜0.01）的形成。因此，古尼虫草多糖有很好的抗衰老作用。

The anti-aging effect of Cordyceps gunnii (Berk.) Berk. Polysaccharide (G-50) on the senescent mice was studied. D-galactose-induced senescent mice were divided into model, low-dose, middle-dose and high-dose groups. 11 Days later, the mice of the low-dose, middle-dose and high-dose groups were gastricly lavaged with 50% polysaccharide with its dose being of 100, 200 and 400 mg/kg, respectively. After 45 days, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the MDA contents in serum and brains were observed. Results showed that Cordyceps gunnii (Berk.) Berk. polysaccharide improved SOD and GSH－Px activities and obviously inhibited the formation of MDA in serum and brains, indicating that the Cordyceps gunnii (Berk.) Berk. polysaccharide had good anti-aging effect.

天津科技大学启动基金（0200060）；人事部中国博士后科学基金（20060400709）资助项目