猪毛菜乙醇提取物降压有效性的实验研究

Antihypertensive Effects of Alcoholic Extracts from Salsola

摘要:

目的：建立左旋硝基精氨酸诱发的高血压大鼠模型，观察猪毛菜乙醇提取物对高血压模型大鼠的降压效果，测其LD50。方法：采用腹腔注射左旋硝基精氨酸制造大鼠高血压模型，灌胃给大鼠不同剂量的猪毛菜乙醇提取物，考察降压作用。用小鼠灌胃考察急性毒性。结果：三个剂量组均有不同程度的降压作用，给药前后比较差异有高度显著性（p均<0.01）。结论：猪毛菜乙醇提取物对左旋硝基精氨酸引起的高血压模型大鼠具有降压作用。猪毛菜乙醇提取物LD50为14.5008 g/kg，95%的可信限为11.5455~18.2206 g/kg。

Abstract:

Objective: to study antihypertensive effects of alcoholic extracts from salsola using hypertension model rats induced by Nω-Nitro-L-Ariginine (L-NNA). Methods: For achieving murine hypertension models, L-NNA was intraperitoneal injected into rats, then different dose of the alcohol extracts were perfused into the stomach of rats. Result: In 2 weeks after giving the medicine, the pressure of the rats were decreased in different degree in three treated groups. There was statistically significant difference in comparison of the antihypertensive effects before and after giving medicine (all p<0.01). Conclusion: Alcoholic extracts from salsola had effective antihypertensive activity for rate induced by L-NNA. Its LD50, and its confidence limit of 95% were 14.5008 g/kg and 11.5455~18.2206 g/kg, respectively.