Abstract:Objective: To study the combined extraction techniques of glycyrrhizic acid and flavonoids from compound of licorice and chrysanthemum. Methods: The effects of extraction time, extraction temperature, the ratio of water to solid and extraction times on the extraction rate of glycyrrhizic acid and flavonoids were investigated. And the optimal extraction conditions were determined by orthogonal experiments. Results: The optimal combined extraction time, temperature, the ratio of water to solid and extraction times were 3 h, 90 ℃, 12:1 and 2, respectively.