辛烯基琥珀酸酯化琼脂对海藻酸钠微胶囊包埋效果的改善作用

Octenyl Succinic Acid Esterified Agar Improves the Embedding Effect of Sodium Alginate Microcapsules

摘要:

将辛烯基琥珀酸酯化琼脂（OSAR）与海藻酸钠（Alg）混合，作为复合壁材用于制备大豆油微胶囊。考察了改性琼脂占比、芯材添加量、乳化温度、氯化钙浓度等因素对微胶囊载油率的影响，并研究复合壁材对大豆油微胶囊包埋产率、乳液与微球性质和形态、体外消化释放率及氧化稳定性的影响。结果表明：复合壁材载油率随改性琼脂占比（OSAR:Alg=0.5:1~3:1）增加先上升后下降趋势；随芯材添加量（1%~5%）增加显著提高而后下降趋势；随乳化温度（40~65 ℃）的升高而降低至平缓；随氯化钙浓度（1%~5%）增加先平稳后下降趋势；复合壁材（OSAR:Alg=1:1）与纯海藻酸钠相比，包埋产率提高了27.9%，乳液稳定性提高了56.86%，表面油含量降低60.0%、包埋效率提高了3.65%，芯材大豆油体外消化释放率和氧化稳定性也明显提高，获得的微球粒径更小、颗粒表面无孔洞，其载油量达40.5%。该研究表明辛烯基琥珀酸酯化琼脂极大地改善了海藻酸钠微胶囊包埋效果，适合应用于构建脂性物质的包封与递送系统。

Abstract:

Octenyl succinic acid esterification agar (OSAR) and sodium alginate were mixed to form a composite wall material to prepare soybean oil microcapsules. The effects of the proportion of modified agar, core material amount, emulsification temperature and calcium chloride concentration on the oil loading rate of microcapsules were investigated. The effects of the composite wall materials on the embedding yield of soybean oil microcapsules, the properties and morphology of emulsion and microspheres, the in vitro digestion-release rate and the oxidation stability were also studied. The results showed that the oil loading rate of the composite wall material increased first and then decreased with the increase of the proportion of modified agar (OSAR: Alg = 0.5:1 ~ 3:1), and increased significantly and then decreased with the increase of core material content (1%~5%). The oil loading rate of the composite wall material decreased and then levelled off with the increase of emulsification temperature (40~65 ℃), and remained constant first and then decreased with the increase of calcium chloride concentration (1%~5%). Compared with pure sodium alginate, the composite wall material (OSAR: Alg=1:1) increased encapsulation efficiency by 27.9%, increased emulsion stability by 56.9%, decreased surface oil content by 60%, increased embedding efficiency by 3.65%, and increased significantly the in vitro digestion-release rate and oxidation stability of the core soybean oil. The obtained microspheres were smaller in size with no holes on the surface and oil loading up to 40.5%. This research showed that octenylsuccinate esterified agar greatly improved the embedding effect of sodium alginate microcapsules, and is suitable for constructing encapsulation and delivery systems for lipophilic substances.