Abstract:To investigate the effects of Ginkgo biloba extract on proliferation and apoptosis of thyroid cancer cells. The cultured cells were divided into blank group, low concentration ginkgo leaf group, medium concentration ginkgo leaf group and high concentration ginkgo leaf group. The proliferation, apoptosis, invasion, migration and adhesion ability of the four groups were analyzed, and the expression of apoptosis-related protein p53, B lymphoma-2 gene (Bcl-2) and Bax were detected. The results showed that the cell proliferation rate and apoptotic rate of high concentration Ginkgo biloba leaves group at 72 h were 14.25%, lower than that of the other three groups, and 81.64%, higher than those of the other three groups, respectively. The number of migration, invasion and adhesion of thyroid cancer cells in the high concentration Ginkgo biloba group were 25.66, 24.19, 13.02, respectively, lower than that of the other three groups (p<0.05). The relative expression of p53 and Bcl-2 in thyroid cancer cells of high concentration Ginkgo biloba leaves group were 0.36 and 0.26, respectively, lower than that of the other three groups. The relative expression of Bax in high concentration Ginkgo biloba leaves group was 1.79, higher than that of the other three groups (p<0.05). Ginkgo biloba extract can inhibit the proliferation, invasion, migration and adhesion of thyroid cancer cells, and promote cell apoptosis by regulating the expression of apoptosis-related proteins p53, Bcl-2 and Bax in a concentration-dependent manner.
