Digestion, Absorption, and Utilization of Sialic Acid in Different Edible Bird's Nests in Rats
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Abstract:
The digestion, absorption, and utilization of Sialic acid (SA) in peptide-containing and conventional stewed bird's nest products were compared. Male SD rats aged 8 weeks (n=32) were divided into four groups randomly: blank control group (BC), peptide-containing bird's nest group (PB), traditional bird's nest group (TB), and sialic acid standard control group (SC). To evaluate the digestion and absorption of SA, feces and urine were collected over 2 days. Blood was collected intermittently through 60 d consecutive gavage to monitor alteration in plasma free and protein-bound SA, and erythrocyte membrane-bound SA content in order to evaluate exogenous SA utilization. The results of feces and urine did not reveal any significant differences between groups in the SA absorption or retention. The results of 60 d consecutive gavage revealed that plasma free SA concentration (p < 0.005), plasma protein-bound SA content (p < 0.005), and erythrocyte membrane-bound SA content (p < 0.001) were significantly higher in each intervention group compared to the BC group. At 10 d, the protein-bound SA content in the PB group was 36.36% higher than that of BC group (p < 0.05), and the erythrocyte membrane-bound SA in the PB group increased by 28.13% and 13.89% compared to the TB and SC groups (p < 0.05). Sialylation in the blood index could indicate exogenous SA utilization; peptides could promote the utilization of SA; all types of bird's nests with long-term consumption could effectively improve the sialylation level of the body.