研究含肽即食燕窝、常规炖煮燕窝唾液酸（Sialic acid, SA）的消化、吸收与利用状况。8w龄雄性SD大鼠32只，随机分为空白对照组（Blank control, BC）、含肽燕窝组（Peptide-containing edible bird's nest, PB）、常规燕窝组（Traditional edible bird's nest, TB）、唾液酸标准品组（SA standard control, SC），经口灌胃干预。连续2 d收集粪尿，检测唾液酸吸收量和储留量并计算消化、吸收率；连续60 d干预，监测血浆游离、蛋白结合唾液酸、红细胞膜唾液酸含量变化，通过唾液酸化程度评价利用状况。2 d粪尿监测尚未发现各组唾液酸消化、吸收率有统计学差异。连续60 d干预后，各干预组血浆游离唾液酸浓度、血浆蛋白结合唾液酸含量、红细胞膜唾液酸含量（p＜0.005）均高于BC组；干预10 d时，PB组蛋白结合唾液酸含量比BC组提高36.36%（p＜0.05），红细胞膜结合唾液酸比TB组、SC组提高28.13%和13.89%（p＜0.05）。综上，血液的唾液酸化可以反映燕窝唾液酸的利用程度；肽类能促进唾液酸被机体更快速利用；长期食用各类燕窝均能有效提高机体唾液酸化水平且优于摄入游离唾液酸。
The digestion, absorption, and utilization of Sialic acid (SA) in peptide-containing and conventional stewed bird's nest products were compared. Male SD rats aged 8 weeks (n=32) were divided into four groups randomly: blank control group (BC), peptide-containing bird's nest group (PB), traditional bird's nest group (TB), and sialic acid standard control group (SC). To evaluate the digestion and absorption of SA, feces and urine were collected over 2 days. Blood was collected intermittently through 60 d consecutive gavage to monitor alteration in plasma free and protein-bound SA, and erythrocyte membrane-bound SA content in order to evaluate exogenous SA utilization. The results of feces and urine did not reveal any significant differences between groups in the SA absorption or retention. The results of 60 d consecutive gavage revealed that plasma free SA concentration (p < 0.005), plasma protein-bound SA content (p < 0.005), and erythrocyte membrane-bound SA content (p < 0.001) were significantly higher in each intervention group compared to the BC group. At 10 d, the protein-bound SA content in the PB group was 36.36% higher than that of BC group (p < 0.05), and the erythrocyte membrane-bound SA in the PB group increased by 28.13% and 13.89% compared to the TB and SC groups (p < 0.05). Sialylation in the blood index could indicate exogenous SA utilization; peptides could promote the utilization of SA; all types of bird's nests with long-term consumption could effectively improve the sialylation level of the body.