本研究探讨了白扁豆非淀粉多糖（NS-DLP）对Ⅱ型糖尿病大鼠降血糖降血脂作用。建立Ⅱ型糖尿病模型大鼠，采用NS-DLP灌胃干预。4周后，观察各组大鼠胰腺组织的病理学变化，测定大鼠空腹血糖、血脂、血清胰岛素、胰腺炎症因子和氧化应激指标。结果表明，与模型组相比，NS-DLP高剂量（100 mg/kg bw）组大鼠空腹血糖和血清甘油三酯水平分别显著降低了10.36%和29.93%；病理学观察发现NS-DLP高剂量组大鼠胰岛面积和细胞数量明显增加；且NS-DLP高剂量组大鼠血清胰岛素，胰腺丙二醛、白介素6和肿瘤坏死因子-α水平分别显著降低了26.36%、39.13%、41.18%和47.18%；超氧化物歧化酶和过氧化氢酶水平分别显著提高10.38%和148.03%。因此，NS-DLP可通过改善胰腺组织病变、减少胰岛素抵抗、降低胰腺炎症水平、抑制胰腺氧化应激水平，对Ⅱ型糖尿病大鼠发挥降血糖降血脂作用。
This study investigated the hypoglycemic and hypolipidemic effects of non-starch polysaccharide from dolichos lablab L (NS-DLP) in type Ⅱ diabetic rats. A type Ⅱ diabetic rat model was established and a NS-DLP gavage intervention was used. After the 4-week administration, the pathological changes in the pancreatic tissues of each group of rats were examined, and their fasting blood glucose, blood lipids, serum insulin, pancreatic inflammatory factors and oxidative stress parameters were also determined. The results showed that compared with the model group, the fasting blood glucose and serum triglyceride levels of the diabetic rats with a NS-DLP high-dose treatment (100 mg/kg bw) were significantly reduced by 10.36% and 29.93%, respectively. Pathological experiments revealed that the area and cell number of pancreatic islets increased in the NS-DLP high-dose group. Moreover, the levels of serum insulin and pancreatic malondialdehyde, interleukin-6 and tumor necrosis factor-α in the NS-DLP high-group were significantly reduced by 26.36%, 39.13%, 41.18% and 47.18%, respectively, whilst the levels of superoxide dismutase and catalase increased significantly (by 10.38% and 148.03%, respectively). Accordingly, the administration with NS-DLP could exert hypoglycemic and hypolipidemic effects in type Ⅱ diabetic rats, through improving pathological changes in pancreatic tissues, reducing insulin resistance, decreasing pancreatic inflammation, and inhibiting pancreatic oxidative stress.