研究了不同仪器、不同检测方法检测特殊医学用途配方食品的渗透压的检测结果差异情况和现阶段国内外各类特殊医学用途配方食品渗透压状况。收集国内外各类特殊医学用途配方食品样品38个，采用德国GONOTEC 3000-D渗透压仪进行检测，同时选择部分代表性样品使用其他冰点法仪器和露点法仪器进行仪器比对和方法比对。冰点法检测的38个样品的渗透压检测结果范围为89 mOsmol/kg~869 mOsmol/kg，相对标准偏差为0.25%~0.97%；进行比对的样品中，冰点法检测结果平均值的范围为168 mOsmol/kg~640 mOsmol/kg，相对标准偏差为0.18%~1.70%；露点法检测结果平均值的范围为162 mOsmol/kg~594 mOsmol/kg，相对标准偏差为0.61%~4.81%。渗透压较高的样品以氨基酸配方和全营养配方为主，专门用于婴儿的配方样品渗透压检测结果较低；露点法的检测结果低于冰点法，检测结果的稳定性和重复性不及冰点法。检测过程中保持环境温湿度和仪器的稳定性，使用合理的进样量能够减小检测误差。

The result difference of osmotic pressure test of formula food for special medical purpose by different instruments and different methods, and osmotic pressure status of all kinds of formula food for special medical purpose at domestic and abroad at present were studied. 38 samples of formula food for special medical purpose at domestic and abroad were collected and tested with German GONOTEC 3000-D osmometer. Some representative samples were selected to use other freezing point instruments and dew point instruments for instrument comparison and method comparison at the same time. The range for osmotic pressure test results of 38 samples determined by freezing point method was 89 mOsmol/kg~869 mOsmol/kg, and the relative standard deviation was 0.25%~0.97%; among the samples for comparison, the average range for the test results of freezing point method was 168 mOsmol/kg~640 mOsmol/kg, and the relative standard deviation was 0.18%~1.70%; the average range for the test results of dew point method was 162 mOsmol/kg~594 mOsmol/kg, and the relative standard deviation was 0.61%~4.81%. The samples with high osmotic pressure were mainly amino acid formula and total nutrition formula, and the infants formula samples results of osmotic pressure test were low; the result of dew point method was lower than that of freezing point method, and the stability and repeatability of the test results were not as good as the freezing point method. The detection error can be reduced by keeping the temperature and humidity of the environment and the stability of the instrument, and using reasonable injection quantity.

国家市场监督管理总局食品补充检验方法研制项目（2019）