[关键词]
[摘要]
酒精性肝损伤是由于长期过量饮酒而导致的肝脏损害,严重时可导致肝细胞坏死,甚至引发肝功能衰竭。目前,寻找有效地干预酒精性肝损伤的活性物质成为各个领域研究的热点。多糖是重要的天然产物资源,广泛存在于植物、动物、真菌中,且安全无毒,具有保护肝脏的作用,能有效地治疗酒精性肝损伤,因此将多糖开发为干预酒精性肝损伤的新型药物具有较高的潜在价值。国内外对于多糖干预酒精性肝损伤的研究也日渐深入,发表了大量的研究结果。该综述从酒精性肝损伤的发病机制、干预酒精性肝损伤的多糖类型以及多糖干预酒精性肝损伤的作用机制进行了归纳总结,并对多糖在干预酒精性肝损伤方面的前景进行了展望,以期对后者的研究有一定的参考和借鉴价值。
[Key word]
[Abstract]
Alcoholic liver disease (ALD) refers to liver damage caused by long-term heavy drinking, and can lead to hepatocellular necrosis and even liver failure in severe cases. The search for active substances with ameliorating effects on ALD has recently become a hot topic focus for researchers in various fields. Polysaccharides represent a major class of natural product, and are widely found in plants, animals, and fungi; they are safe and non-toxic, and can have protective effects on the liver, offering hope for an effective ALD treatment. Therefore, polysaccharides display high potential for development of new drugs for ALD. Research into the ameliorating effects of polysaccharides in ALD has rapidly proliferated, and a large number of research results have been published. This review summarizes the pathogenesis of ALD, the types of polysaccharides that can be used to treat ALD, and the mechanism underlying polysaccharide action in ALD, It also discusses future prospects for polysaccharide mediated intervention in ALD, in the hope of providing a frame of reference for future research.
[中图分类号]
[基金项目]
广东省基础与应用基础研究基金项目(2019A1515011283);广东省科技项目(2017A020108006)