宋也好,游慧婷,姚于飞,吴睿婷,付王威,万敏,李文娟.鱼腥草多糖对脂多糖诱导大鼠慢性炎症肺损伤的保护作用[J].,2020,36(6):1-8.
鱼腥草多糖对脂多糖诱导大鼠慢性炎症肺损伤的保护作用
Protective Effect of Houttuynia cordata Polysaccharide on LPS Induced Chronic Inflammatory Lung Injury in Rats
投稿时间:2019-12-31  
DOI:10.13982/j.mfst.1673-9078.2020.6.1291
中文关键词:  鱼腥草多糖  慢性炎症  肺损伤  炎症因子
英文关键词:Houttuynia cordata polysaccharide  chronic inflammation  lung injury  inflammatory factors
作者简介:宋也好(1992-),女,硕士生,研究方向:多糖生物活性 通讯作者:李文娟(1982-),女,博士,教授,研究方向:天然产物活性功能与研发
基金项目:国家自然科学基金地区基金项目(81860713);国家自然科学基金面上项目(31872900)
作者单位
宋也好 (1.南昌大学食品科学与技术国家重点实验室,江西南昌 330047) 
游慧婷 (1.南昌大学食品科学与技术国家重点实验室,江西南昌 330047) 
姚于飞 (2.江西中医药大学附属医院,江西南昌 330006) 
吴睿婷 (1.南昌大学食品科学与技术国家重点实验室,江西南昌 330047) 
付王威 (1.南昌大学食品科学与技术国家重点实验室,江西南昌 330047) 
万敏 (1.南昌大学食品科学与技术国家重点实验室,江西南昌 330047) 
李文娟 (1.南昌大学食品科学与技术国家重点实验室,江西南昌 330047) 
AuthorInstitution
SONG Ye-hao (1.State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China) 
YOU Hui-ting (1.State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China) 
YAO Yu-fei (2.Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China) 
WU Rui-ting (1.State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China) 
FU Wang-wei (1.State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China) 
WAN Min (1.State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China) 
LI Wen-juan (1.State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China) 
摘要点击次数: 64
全文下载次数: 39
中文摘要:
      本文探究了鱼腥草多糖(HCP)对脂多糖(LPS)诱导大鼠慢性炎症肺损伤的影响。尾静脉注射LPS构建慢性炎症模型,测定全血白细胞(WBC)、单核细胞数量及血清超敏C反应蛋白(hs-CRP)含量;观察肺组织病理学改变;测定肺组织中抗氧化物酶、丙二醛(MDA)、一氧化氮(NO)、一氧化氮合酶含量及炎症细胞因子水平。结果表明,与LPS组相比,HCP高剂量处理组WBC、单核细胞数量和血清hs-CRP含量分别显著降低了17.89%、38.37%和35.61%;病理学观察发现HCP处理组能明显缓解肺组织水肿等病理状态;HCP处理组的肺组织抗氧化物酶活性显著升高,且HCP高剂量处理组中MDA、NO、iNOS、tNOS含量及细胞因子IL-6、IL-1β、TNF-α水平分别显著降低了28.79%、22.88%、37.06%、27.49%、34.19%、38.84%和52.27%。因此,HCP可以通过减少炎症细胞释放、改善肺水肿等病理形态、抑制机体氧化应激水平以及减少相关炎症因子分泌来保护大鼠慢性炎症肺损伤。
英文摘要:
      The effect of Houttuynia cordata polysaccharide (HCP) on LPS induced chronic inflammatory lung injury was investigated in the present work. The chronic inflammatory model was established via the intravenous injection of LPS, and the number of WBC, monocyte and the content of serum hypersensitive C-reactive protein (hs-CRP) were measured in this work. Furthermore, the pathological changes of lung tissue were observed. The contents of antioxidant enzyme, malondialdehyde (MDA), nitric oxide (NO), nitric oxide synthase and the level of cytokines in lung tissue were determined. The results showed that, the content of WBC, monocyte and serum hs-CRP in high dose treatment of HCP group were significantly reduced by 17.89%, 38.37% and 35.61% respectively, when compared to LPS group. Moreover, pathological observation showed that HCP treatment group could alleviate significantly the pathological state of pulmonary edema. Meanwhile, the activity of antioxidant enzyme in lung tissue of HCP treatment group was significantly increased. Strikingly, the content of MDA, NO, iNOS, tNOS and the cytokine levels of IL-6, IL-1β, TNF-α in high dose treatment of HCP group were remarkably reduced by 28.79%, 22.88%, 37.06%, 27.49%, 34.19%, 38.84% and 52.27%, respectively. In conclusion, the protective effects of HCP against chronic inflammatory lung injury in rats was linked to its activities on the reduction of inflammatory cell secretion, the alleviation of pulmonary edema and other pathological states, the inhibition of oxidative stress, and the reduction of the release of inflammatory factors.
查看全文  查看/发表评论  下载PDF阅读器
关闭