本文探究了鱼腥草多糖（HCP）对脂多糖（LPS）诱导大鼠慢性炎症肺损伤的影响。尾静脉注射LPS构建慢性炎症模型，测定全血白细胞（WBC）、单核细胞数量及血清超敏C反应蛋白（hs-CRP）含量；观察肺组织病理学改变；测定肺组织中抗氧化物酶、丙二醛（MDA）、一氧化氮（NO）、一氧化氮合酶含量及炎症细胞因子水平。结果表明，与LPS组相比，HCP高剂量处理组WBC、单核细胞数量和血清hs-CRP含量分别显著降低了17.89%、38.37%和35.61%；病理学观察发现HCP处理组能明显缓解肺组织水肿等病理状态；HCP处理组的肺组织抗氧化物酶活性显著升高，且HCP高剂量处理组中MDA、NO、iNOS、tNOS含量及细胞因子IL-6、IL-1β、TNF-α水平分别显著降低了28.79%、22.88%、37.06%、27.49%、34.19%、38.84%和52.27%。因此，HCP可以通过减少炎症细胞释放、改善肺水肿等病理形态、抑制机体氧化应激水平以及减少相关炎症因子分泌来保护大鼠慢性炎症肺损伤。

The effect of Houttuynia cordata polysaccharide (HCP) on LPS induced chronic inflammatory lung injury was investigated in the present work. The chronic inflammatory model was established via the intravenous injection of LPS, and the number of WBC, monocyte and the content of serum hypersensitive C-reactive protein (hs-CRP) were measured in this work. Furthermore, the pathological changes of lung tissue were observed. The contents of antioxidant enzyme, malondialdehyde (MDA), nitric oxide (NO), nitric oxide synthase and the level of cytokines in lung tissue were determined. The results showed that, the content of WBC, monocyte and serum hs-CRP in high dose treatment of HCP group were significantly reduced by 17.89%, 38.37% and 35.61% respectively, when compared to LPS group. Moreover, pathological observation showed that HCP treatment group could alleviate significantly the pathological state of pulmonary edema. Meanwhile, the activity of antioxidant enzyme in lung tissue of HCP treatment group was significantly increased. Strikingly, the content of MDA, NO, iNOS, tNOS and the cytokine levels of IL-6, IL-1β, TNF-α in high dose treatment of HCP group were remarkably reduced by 28.79%, 22.88%, 37.06%, 27.49%, 34.19%, 38.84% and 52.27%, respectively. In conclusion, the protective effects of HCP against chronic inflammatory lung injury in rats was linked to its activities on the reduction of inflammatory cell secretion, the alleviation of pulmonary edema and other pathological states, the inhibition of oxidative stress, and the reduction of the release of inflammatory factors.

国家自然科学基金地区基金项目（81860713）；国家自然科学基金面上项目（31872900）