本文探讨了海参肽与玛咖粉、枸杞子提取物、红景天提取物配伍协同缓解体力疲劳的作用效果。将400只健康雄性小鼠分为4批（N=100），分别进行负重游泳实验以及运动后血清尿素氮含量测定、血乳酸测定、肝糖原测定试验。每批随机分为10小组（n=10），其中一组作为阴性对照组，其余9组作为海参肽复合物、植物提取物、海参肽三组低、中、高剂量试验组，其分别相当于人体推荐剂量的5、10、30倍。灌胃给药，每天1次，连续30 d，对照组给予等量蒸馏水。结果表明，与对照组相比，中、高剂量海参肽复合物负重游泳时间分别延长80.06%（p<0.05）和99.13%（p<0.01），运动后血清尿素浓度分别减少26.21%、30.74%（p<0.05），血乳酸曲线下面积分别减少26.90%、32.11%（p<0.05），且效果均优于植物提取物组和海参肽组，肝糖原变化不显著（p>0.05）。海参肽与玛咖粉、枸杞子提取物、红景天提取物配伍后具有较好的缓解体力疲劳的作用，且其作用效果均优于单独的海参肽与植物提取物。

The was investigated effect of the compound of sea cucumber peptide, Maca powder, Wolfberry extract and Rhodiola rosea extract on relieving physical fatigue. Four hundred of healthy male mice were divided into 4 batches (N=100), on which weight loading swimming experiment, serum urea nitrogen test, blood lactic acid test, and liver glycogen test after exercise were conducted respectively. Each batch was randomly divided into 10 groups (n=10), one of which was used as the negative control group, and the other 9 groups as the low, medium and high dose of three experimental groups (sea cucumber peptide complexes, sea cucumber peptide, plant extracts). Low (0.2 g/kg?bw), medium (0.4 g/kg?bw), and high (1.2 g/kg?bw) doses are equivalent to 5, 10, and 30 times the recommended doses of the human body. The drug was administered by intragastric administration once a day for 30 days, and the control group was given an equal amount of distilled water. The changes of exhaustive swimming time, serum urea nitrogen content, lactate levels and hapatic glycogen content after exercise in each group were compared. Compared with the control group, the weight loading swimming times of the groups administered the medium and high-dose sea cucumber peptide complexes was extended by 80.06% (p<0.05) and 99.13% (p<0.01) respectively. In the meantime, the serum urea concentrations after exercise decreased by 26.21% (p<0.05) and 30.74% respectively (p<0.05), the area under the curve of blood lactic acid were reduced by 26.90% (p<0.05) and 32.11% (p<0.05) respectively. It can be seen that the sea cucumber peptide has better effect on relieving fatigue by compounding with Maca powder, Wolfberry extract and Rhodiola rosea extract.

国家重点研发计划项目（2018YFC0311203）