研究了赶黄草水提取物对高脂饮食联合链脲佐菌素（STZ）诱导的Ⅱ型糖尿病大鼠的降血糖作用。随机选取10只SD大鼠作为正常对照组（NC），其余大鼠经4 w高脂饮食喂养后，腹腔注射小剂量STZ（35 mg/kg）建立Ⅱ型糖尿病大鼠模型。造模成功后随机分为：模型组（MC）、二甲双胍阳性对照组（PC，500 mg/kg/d）、赶黄草水提物组（PCP，545 mg/kg/d），每组10只。干预4 w后，检测各组大鼠血糖、血脂、抗氧化水平，肝、胰HE染色观察组织病变。结果表明，与模型组相比，赶黄草水提物组空腹血糖（FBG）、糖化血红蛋白（HbA1c）水平分别降低43.93%、77.05% (p<0.05)，血清高密度脂蛋白胆固醇（HDL-C）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）分别升高80.00%、76.32%、42.75%、32.12% (p<0.05)，丙二醛（MDA）含量降低26.89%（p<0.01）。赶黄草水提物能显著降低Ⅱ型糖尿病大鼠血糖水平，改善胰岛素抵抗，其机制可能与其发挥抗氧化作用，减少氧化应激有关。

The hypoglycemic effect of extract of Penthorum chinense Pursh (PCP) on a high fat diet and streptozotocin (STZ)-induced diabetic rats was investigated. The efficacy of orally administer PCP (545 mg/kg/day) for 4 weeks were evaluated in high-fat diet and STZ (35mg/kg.) induced diabetic rats, and metformin (500 mg/kg/day) was used as a positive control. A range of parameters, including blood glucose and lipid were tested to evaluate its anti-hyperglycemic effects. Moreover, superoxide dismutase (SOD), malonaldehyde (MDA), glutathione peroxidase (GSH-Px), and catalase (CAT) were performed to determinate their antioxidant activities. The fasting blood glucose and HbAc1 level of PCP treatment group decreased by 43.93% and 77.05%, respectively, when compared with the diabetic rat group (p<0.05). The activities of antioxidant enzymes including GSH-Px, SOD and CAT were significantly improved by 76.32%, 42.75% and 32.12% (p<0.05), respectively. PCP was also found to reduce the levels of MDA (p<0.01). Meanwhile, the histology results showed the extract of PCP could protect against liver and pancreas damages. This study showed that the extract of PCP modulated hyperglycemia in high-fat diet and STZ-induced diabetic rats, which might be attributed to enriching antioxidant enzymes activities.

泸州市科技计划项目（2012-S-36）