为研究以刺梨、蜂胶、山楂为主要原料的口服液对膳食诱导高血脂症的降血脂功效，通过喂养高脂饲料建立高血脂模型小鼠。将喂养高脂饲料的小鼠分为高脂模型组、刺梨原汁组、刺梨蜂胶组、刺梨山楂组、刺梨蜂胶山楂组共5组，各组灌胃不同的刺梨口服液28 d，灌胃期间测定小鼠的体重、采食量。28 d后测定小鼠血清及肝脏的总胆固醇（Total Cholesterol，TC）、甘油三酯（Triglyceride，TG）、高密度脂蛋白（High-density Lipoprotein，HDL-C）、丙二醛（Malondialdehyde，MDA）含量。研究发现刺梨口服液可有效缓解高血脂症状，灌胃刺梨蜂胶山楂口服液的小鼠血清中的总胆固醇（TC）显著性降低了23.94%（p<0.05），血清甘油三酯（TG）显著降低了46.41%（p<0.05），血清中的MDA含量显著性降低了73.83%（p<0.05）。研究表明刺梨蜂胶山楂口服液具有良好的降血脂功效，可有效延缓脂质过氧化速率。

The aim of this work was to investigate the effect of oral liquid with Rosa roxburghii Tratt, propolis and Crataegus as main raw materials on hypolipidemic activity induced by diet-induced hyperlipidemia, the hyperlipidemic model mice were established by feeding high fat diet. The hyperlipidemia mice were divided into high-fat model group, Rosa roxburghii Tratt juice group, Rosa roxburghii Tratt propolis group, Rosa roxburghii Tratt Crataegus group, and Rosa roxburghii Tratt propolis Crataegus group, and each group received different Rosa roxburghii Tratt oral liquid for 28 days. The body weight and feed intake of the mice were measured during the gavage. Total cholesterol (TC), Triglyceride (TG), High-density Lipoprotein (HDL-C), Malondialdehyde (MDA) in serum and liver of mice were measured after 28 days feed. Results showed that the Rosa roxburghii Tratt oral liquid could effectively alleviate hyperlipidemia symptoms. The total cholesterol (TC) in the serum of the mice administrated with the Rosa roxburghii Tratt propolis Crataegus oral liquid was significantly reduced by 23.94% (p<0.05), serum triglyceride (TG) was significantly reduced by 46.41%(p<0.05), and the MDA content in serum was significantly reduced by 73.83% (p<0.05). These indicated that the Rosa roxburghii Tratt propolis Crataegus oral liquid had good hypolipidemic effect and could effectively delay the rate of lipid peroxidation.

黔科合重大专项（字[2013]6006-2）